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tag chaperone mediated autophagy evolution disease medicine

Eat Yourself to Live: Autophagy’s Role in Health and Disease
Vikramjit Lahiri and Daniel J. Klionsky | Mar 1, 2018 | 10+ min read
New details of the molecular process by which our cells consume themselves point to therapeutic potential.
A colored microscope image of a cross section of a human artery filled with fatty plaques
Protein-Recycling Process Protective Against Arterial Plaques
Clare Watson | Aug 1, 2022 | 2 min read
A team of scientists has found that in mice, a cellular housekeeping pathway protects against a major cause of heart attacks and strokes.
Waste-Management Consultant
Megan Scudellari | Nov 1, 2013 | 9 min read
By audaciously pursuing an abandoned area of research, Ana María Cuervo discovered how cells selectively break down their waste, and revealed the health consequences when that process malfunctions.
Longevity
Jill Adams(juadams@the-scientist.com) | May 8, 2005 | 7 min read
During autophagy-literally "self-eating"-cells deliver cytoplasmic constituents, including whole organelles, to the lysosome for degradation.
The Genes of Parkinsons Disease
Bobby Thomas and M. Flint Beal | Feb 1, 2011 | 7 min read
By Bobby Thomas and M. Flint Beal The Genes of Parkinson’s Disease The minority of Parkinson’s cases now known to have genetic origins are shedding light on the cellular mechanisms of all the rest, bringing researchers closer to a cause—and perhaps a cure. Gerald Slota It took centuries for the slumped posture, trembling hands, poor balance, and cognitive impairments that characterize Parkinson’s disease (PD) to be recognized as manifest
The Genes of Parkinson’s Disease
Bobby Thomas and M. Flint Beal | Feb 1, 2011 | 10 min read
The minority of Parkinson’s cases now known to have genetic origins are shedding light on the cellular mechanisms of all the rest, bringing researchers closer to a cause—and perhaps a cure.
Week in Review: June 15–19
Tracy Vence | Jun 19, 2015 | 3 min read
Eye on MERS; HIV vaccine design; evolution of Ebola; CRISPR meets optogenetics
Protein Folding: Theory Meets Disease
Philip Hunter | Sep 7, 2003 | 10+ min read
Protein folding raises some of biology's greatest theoretical challenges. It also lies at the root of many diseases. For example, the fundamental question of whether a protein's final tertiary conformation, sometimes called the native state, can be predicted from its primary amino acid sequence is also of vital importance in understanding the protein's potential capacity to form disease-inducing aggregates. MISS A FOLD, PROMPT A DISEASE Here's a list of protein folding-related disease catego
The Proteasome: A Powerful Target for Manipulating Protein Levels
John Hines and Craig M. Crews | May 1, 2017 | 10+ min read
The proteasome’s ability to target and degrade specific proteins is proving useful to researchers studying protein function or developing treatments for diseases.
The Role of Mom’s Microbes During Pregnancy
Carolyn A. Thomson and Kathy D. McCoy | Aug 1, 2021 | 10+ min read
Bacteria in the gut influence the production of antibodies and themselves secrete metabolites. In a pregnant woman, these compounds may influence immune development of her fetus.

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