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tag phosphatidylinositol pi 3 kinase neuroscience evolution

From kinase to cancer
Lewis Cantley | Dec 1, 2007 | 10+ min read
From kinase to cancer The story of discovering PI3 kinase, and what it means for a fundamental pathway in cancer. By Lewis Cantley In 1987 I attended a meeting at Cold Spring Harbor on phosphatidylinositol signaling that turned out to be pivotal for me. A few years earlier I'd helped show that a phosphatidylinositol (PI) kinase activity copurified with various oncoprotein tyrosine kinases, and that this association was critical for the ability of these oncoproteins to tran
From kinase to cancer
Lewis Cantley | Dec 1, 2007 | 10 min read
From kinase to cancer The story of discovering PI3 kinase, and what it means for a fundamental pathway in cancer. By Lewis Cantley Related Articles 1 I suspected that this enzyme might be placing a phosphate on the 3 position of the inositol ring to produce phosphatidylinsitol-3-phosphate (PI-3-P), but I realized that this would be heretical to the field and would require rigorous chemical proof, since PI-3-P had not been previously described. So, at the Col
Cell-Signaling A Cascade of Kinases, Phosphatases, and Cytokines
Deborah Noble | Jul 4, 1999 | 8 min read
Date: July 5, 1999Table of Cell Signaling Tools At today's research pace, new signaling mechanisms within and between cells are emerging not one by one but in a chain reaction. Each new discovery has strong implications for previously established models, sometimes overturning several assumptions at once. With such a large number of interacting systems--from cell adhesion to differentiation and apoptosis--and receptor pathways, keeping up with the wealth of cell-signaling research tools can be l
Signal Transduction
The Scientist Staff | May 23, 1999 | 5 min read
Edited by: Steve Bunk H. Dudek, S.R. Datta, T.F. Franke, M.J. Birnbaum, R. Yao, G.M. Cooper, R.A. Segal, D.R. Kaplan, M.E. Greenberg, "Regulation of neuronal survival by the serine-threonine protein kinase Akt," Science, 275:661-5, Jan. 31, 1997. (Cited in more than 245 papers since publication) Alex Toker Comments by Henryk Dudek, senior scientist, neurosciences group, Ontogeny Inc., Cambridge, Mass., and Michael E. Greenberg, professor of neurology, Children's Hospital, Harvard Medical Sc
Cantley Changes Jobs
Bob Grant | Sep 14, 2012 | 1 min read
Renowned cancer researcher Lewis Cantley is leaving Harvard to lead a new cancer center at Weill Cornell Medical College and NewYork-Presbyterian Hospital.
How Cells Find Their Way
Laura Defrancesco | Sep 2, 2001 | 5 min read
Organisms need to sense their environment. By sensing, they can develop, heal wounds, protect against invaders, and create blood vessels. Chemotaxis, or directional sensing, allows cells to detect chemicals with exquisite sensitivity. Some chemotactic cells can sense chemical gradients that differ by only a few percent from a cell's front to its back. Although discovery of the molecule types involved in chemotaxis, as with other kinds of cell signaling events, has mounted, the details of how thi
The Enigmatic Membrane
Muriel Mari, Sharon A. Tooze, and Fulvio Reggiori | Feb 1, 2012 | 10+ min read
Despite years of research, the longstanding mystery of where the autophagosome gets its double lipid bilayers is not much clearer.
Hot Papers
The Scientist Staff | Oct 14, 1990 | 5 min read
M.J. Birnbaum, Identification of a novel gene encoding an insulin-responsive glucose transporter protein, Cell, 57:305-15, 21 April 1989. Morris J. Birnbaum (Harvard Medical School, Boston): Almost 10 years prior to the publication of this paper, other researchers formulated a model to explain the rapid and reversible insulin-stimulated increase in glucose uptake in responsive target tissues: the hormone effects the redistribution of hexose transporter proteins from a latent intracellular comp
Untangling Neuronal Calcium Signaling
Amy Adams | Jan 20, 2002 | 10 min read
From the very moment of conception, calcium plays a pivotal role in fetal development. It rushes in as a wave around the egg to herald the sperm's arrival, binding to proteins that help kick off the whole developmental process. From this first influx, calcium continues to play a critical role in how the body's cells respond to outside signals. Calcium tells muscles to contract and nerves to release neurotransmitters, and is at least part of the signal that helps people form and retain memories.
Illuminating Behaviors
Douglas Steinberg | Jun 1, 2003 | 6 min read
Courtesy of Genevieve Anderson If not for Nobel laureates Thomas Hunt Morgan, Eric R. Kandel, and Sydney Brenner, the notion of a general behavioral model might seem odd. Behaviors, after all, are determined by an animal's evolutionary history and ecological niche. They are often idiosyncratic, shared in detail only by closely related species. But, thanks to Morgan's research in the early 20th century, and Kandel's and Brenner's work over the past 35 years, the fly Drosophila melanogaster, t

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