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Epigenetic Changes Drive Cancer 
An analysis of almost 700 different tumors revealed that DNA methylation drives tumorigenesis just like genetic mutations do. 
Epigenetic Changes Drive Cancer 
Epigenetic Changes Drive Cancer 

An analysis of almost 700 different tumors revealed that DNA methylation drives tumorigenesis just like genetic mutations do. 

An analysis of almost 700 different tumors revealed that DNA methylation drives tumorigenesis just like genetic mutations do. 

epigenetics

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Predict Functional Genomics with Confidence
The Scientist Staff | Mar 1, 2024 | 1 min read
An advanced multiomics solution allows researchers to predict gene expression, chromatin accessibility, and enhancer state from one DNA sample.
A graphic of two stem cells colored pink and blue splitting from each other, with binary code shown in the background.
Fixing the Problem With Induced Pluripotent Stem Cells
Tanvir Khan, PhD | Oct 31, 2023 | 4 min read
A new strategy prevents reprogramming-induced epigenetic aberrations in human induced pluripotent stem cells.
Researchers can obtain epigenetic information in addition to genetic insights from a single DNA sample.
The Six-Base Genome Reveals Multimodal Data from a Single DNA Sample
The Scientist and biomodal | 4 min read
To gather multiomic insights, researchers used to combine data from multiple workflows, but duet evoC provides more information from less sample in one workflow.
A doctor reaches out to touch a lung tumor, highlighted in red.
Silencing Epigenetic Complexes Re-sensitizes Drug-Resistant Cancer Cells
Rachael Moeller Gorman | Sep 25, 2023 | 4 min read
Researchers studying lung cancer cell lines found that chromatin remodeling underlies one type of osimertinib resistance.
An elderly person in beige shirt and a knitted, cream-colored vest holds a wooden walking stick.
New Epigenetic Clocks May Confirm Extreme Age
Ida Emilie Steinmark, PhD | Sep 8, 2023 | 4 min read
How will a new version of epigenetic clocks aimed at validating the age of people older than 100 years of age balance accuracy and anonymity?
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Epigenetics in a Dish
The Scientist | 2 min read
Jonathan Weissman and Luke Gilbert share how they developed several CRISPR-based epigenetic editors and how these tools differ from traditional CRISPR.
Image of methylated DNA
Stress Increases Biological Age, But Recovery Can Revert It
Alejandra Manjarrez, PhD | Apr 21, 2023 | 2 min read
A new study relying on DNA methylation clocks suggests that the biological age of mouse and human cells can fluctuate in response to stressful events.
a trio of infant mice, two brown mice on the ends and one white mouse in the middle
Mice Pass Epigenetic Tweaks to Pups
Katherine Irving | Feb 17, 2023 | 5 min read
An engineered methylation pattern persisted for four generations of mice, demonstrating transgenerational epigenetic inheritance can occur in mammals.
Epigenetic Influences and Mechanisms in Cancer
Epigenetic Influences and Mechanisms in Cancer
The Scientist Staff | 1 min read
In this webinar, Özgen Deniz and Christina Leslie will discuss how epigenetic regulation affects oncogenesis.
A younger-looking mouse next to an older-looking one
Epigenetic Manipulations Can Accelerate or Reverse Aging in Mice
Alejandra Manjarrez, PhD | Jan 12, 2023 | 4 min read
Repairing damaged DNA appears to drive aging by causing the loss of epigenetic information, but restoring that information reverses such effects, a study finds.
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Our Favorite Genetics Stories of 2022
Christie Wilcox, PhD | Dec 22, 2022 | 4 min read
This year’s stories highlight the expanding versatility of genetic techniques and the increasing utility of such research in all life science fields.
<em >The Scientist</em>&rsquo;s Journal Club: Cancer
The Scientist’s Journal Club: Cancer
The Scientist | 1 min read
Scientists present the latest research on immune cell responses to cancer, the role of epigenetics in cancer, and molecular imaging of the tumor microenvironment.
zebrafish in an aquarium
Epigenetics May Remember Ancestors’ Mutations
Holly Barker, PhD | Dec 1, 2022 | 4 min read
Parents’ mutations, even if they’re not inherited by offspring, could affect subsequent generations through changes to epigenetic marks, a study finds.
Blue 3D illustration of X-shaped chromosomes
X Chromosome Silenced in Some Cancers in Males
Natalia Mesa, PhD | Nov 11, 2022 | 3 min read
A study finds that XIST, the gene that shuts down one X chromosome in people who have two, is linked to cancer in males. 
Methylation Sequencing to Identify Potential Cancer Biomarkeres&nbsp;
Methylation Sequencing in Cancer Detection
The Scientist and Twist Bioscience | 1 min read
Discover how efforts to uncover the genome's methylation patterns advance cancer detection.
Illustration from the epigenetics and the genome infographic
Infographic: How Epigenetic Marks Can Change the Genome
Katarina Zimmer | Nov 1, 2022 | 2 min read
Although epigenetic changes were long thought to largely act on the genome, rather than as part of it, research is now showing that these patterns can, directly or indirectly, change the genetic code.
Cellular DNA and epigenetics
Do Epigenetic Changes Influence Evolution?
Katarina Zimmer | Nov 1, 2022 | 10+ min read
Evidence is mounting that epigenetic marks on DNA can influence future generations in a variety of ways. But how such phenomena might affect large-scale evolutionary processes is hotly debated.
VAI
One Sequence, Many Variations
Van Andel Institute | 5 min read
Andrew Pospisilik explores the epigenetic changes that give organisms the plasticity to change in response to their environments.
A cross-section of a mouse hypothalamus, where cells of the arcuate nucleus are shown in bright green at the bottom.
Methylation in Young Brains May Be Key to Obesity: Mouse Study
Alejandra Manjarrez, PhD | Oct 19, 2022 | 4 min read
Epigenetic events, such as methylation, during early brain development in mice occur in genomic regions associated with BMI in humans, according to a new study.
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