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image: Designing Transition-State Inhibitors

Designing Transition-State Inhibitors

By | May 1, 2012

A transition-state mimic has the power to bind an enzyme at its tipping point as strongly as any available inhibitor and more strongly than most, preventing enzymatic activity. 

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image: Freezing Time

Freezing Time

By | May 1, 2012

Targeting the briefest moment in chemistry may lead to an exceptionally strong new class of drugs.

15 Comments

image: Telomeres in Disease

Telomeres in Disease

By | May 1, 2012

Telomeres have been linked to numerous diseases over the years, but how exactly short telomeres cause diseases and how medicine can prevent telomere erosion are still up for debate.

16 Comments

image: Are Cancer Stem Cells Ready for Prime Time?

Are Cancer Stem Cells Ready for Prime Time?

By | April 1, 2012

A flood of new discoveries has refined our definition of cancer stem cells. Now it’s up to human clinical trials to test if they can make a difference in patients.

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image: Turning T-cells into Cancer Killers

Turning T-cells into Cancer Killers

By | August 10, 2011

Repurposing patient’s own T-cells to recognize antigens on cancer cells caused dramatic improvement in three patients with chronic lymphocytic leukemia.

21 Comments

image: Stem Cells Hit Reverse

Stem Cells Hit Reverse

By | July 31, 2011

A transcription factor can make adult stem cells behave like fetal stem cells.

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image: Interfering with Cancer

Interfering with Cancer

By | January 1, 2011

MicroRNAs may drive the development of leukemia.

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