macrophage, immunology

Whether the finding of a novel mechanism for cancer-related pain can lead to better treatments for neuropathic pain in people remains to be seen.

Research traces the evolution of a gene variant that reduces the risk of Alzheimer’s disease, finding that it originally evolved in response to infectious bacteria.

Researchers turned white blood cells called neutrophils into drug-smuggling “neutrobots,” which penetrated the blood-brain barrier to treat brain cancer in mice.

Following on the success of CAR T cells used to treat cancers of the blood, researchers have launched a Phase 1 clinical trial of genetically modified macrophages to target solid tumors.

Researchers find different distributions of the immune cells in young, older, and diseased eyes.

Imaged in real time in living people, immune cells at the surface of the retina could serve as biomarkers to detect retinal and possibly neurological diseases and track their progression.

Knocking out the receptor for a lipid that causes inflammation rejuvenates macrophage metabolism and restores cognitive function in an Alzheimer’s disease model.

Excess of the inflammatory molecule bradykinin may explain the fluid build-up in the lungs of patients with coronavirus infections. Clinical trials of inhibitors are putting this hypothesis to the test.

The leaky blood vessels and lung fluid build-up in some COVID-19 patients might be explained by the virus’s corruption of an inflammation safeguard.

Studies are underway to test whether giving a shot of BCG vaccine could protect doctors and nurses against COVID-19.

The energy-producing organelles also send out parcels with antimicrobial compounds to help destroy pathogen invaders in macrophages.

From guiding branching neurons in the developing brain to maintaining a healthy heartbeat, there seems to be no job that the immune cells can’t tackle.

In addition to circulating in the blood as immune sentinels, macrophages play specialized roles in different organs around the body.

Time-lapse imaging shows the immune cells transferring chemical signals during pigment pattern formation in developing zebrafish.

Immune cells called macrophages shuttle cellular messages in the skin.

Once thought only to attack neurons, immune cells turn out to be vital for central nervous system function.

Researchers document the diverse roles of immune cells in neuronal health and disease.

Host and bacterial ligands that interact with the same cell-surface receptor induce different activities in human macrophages.