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image: Resistance to HIV Engineered Via CRISPR

Resistance to HIV Engineered Via CRISPR

By | August 3, 2017

Mice transplanted with human hematopoietic stem cells that have an HIV receptor gene, CCR5, disrupted by gene editing allows the animals to ward off HIV infection. 

1 Comment

image: Opinion: Biobanking Has a Consent Dilemma

Opinion: Biobanking Has a Consent Dilemma

By | July 25, 2017

Is the deep uncertainty surrounding fundamental legal and ethical norms putting biobanks in a precarious position? 

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In two early trials, vaccines tailored to the mutations in individuals’ cancers appeared to protect 12 of 19 patients against relapse. 

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A new screening tool flags dozens of papers with potential errors.

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The publicly available database found nearly a third of samples included mutations targeted by either approved drugs or therapies in clinical trials. 

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image: Opinion: Token Pharmacovigilance

Opinion: Token Pharmacovigilance

By | May 23, 2017

A US government website for collecting reports of side effects associated with vaccines is broken. Why has no one noticed?

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Sangamo Therapeutics will use zinc finger nucleases to introduce the gene for a missing clotting factor into the livers of men with hemophilia B.

2 Comments

image: Stem Cell Trial Data Mostly Go Unpublished

Stem Cell Trial Data Mostly Go Unpublished

By | May 5, 2017

Less than half of completed stem cell studies in humans are published in peer-reviewed journals, according to an analysis of regenerative medicine trials. 

1 Comment

image: Cell Lines Gain Cancer-Related Mutations

Cell Lines Gain Cancer-Related Mutations

By | April 27, 2017

A screen of human embryonic stem cell lines finds several that accumulated changes in the gene TP53, including aberrations commonly seen in cancer.

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image: DNA-Based Zika Vaccine Reaches Phase 2

DNA-Based Zika Vaccine Reaches Phase 2

By | April 4, 2017

An NIAID-sponsored clinical trial advances beyond safety testing.

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