genetics & genomics

This year marks the centennial of Calvin Bridges’s description of nondisjunction as proof that chromosomes are vehicles for inheritance.

Tips for tracing transcription in individual cells

Elaine Fuchs has worked on adult stem cells since before they were so named, figuring out how multipotent epidermal cells renew or turn into skin or hair follicles.

A recent exchange of papers is divided over the evidence for compensatory gene expression among wild strains of aneuploid yeast.

Tailored combinations of a reporter and a ligand-binding domain allow for sensing just about any molecule of interest.

Rockefeller University researcher Elaine Fuchs on being a woman in science and her contributions to the burgeoning field of reverse genetics

A biotech company reports that an experimental treatment elongated its CEO’s telomeres. 

The aneuploidy expert shares what she has learned at the American Association for Cancer Research annual meeting.

Sequence analysis of 41 viral strains reveals more than a half-century of change. 

Patients with neonatal progeroid syndrome lack a glucose-releasing hormone, while people with insulin resistance have an abundance.

For the second time, researchers use CRISPR to modify the genomes of nonviable embryos.

An analysis of the genomes of nearly 600,000 healthy individuals reveals a handful of people who appear resistant to certain genetic disorders.

Researchers create a new tree of life, largely composed of mystery bacteria.

Methylation on adenine bases is involved in the dampening of gene expression in mammalian cells, according to a study.

Four apparently unrelated individuals share a common ancestor from whom they inherited a rare mutation that predisposed them to the cancer they share.

Systems-biology approaches offer new strategies for finding hard-to-identify drug targets for cancer.

An open mind and collaborative spirit have taken Hans Clevers on a journey from medicine to developmental biology, gastroenterology, cancer, and stem cells.

Follow Michele Carbone as he tracks down the genetic and environmental drivers of mesothelioma and other cancers.

Scientists build a living cellular organism with a genome smaller than any known in nature.

Their $1.5 billion bid, which topped Thermo Fisher Scientific’s $1.3 billion offer for the genetic analysis company, was rejected.