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tag acute myeloid leukemia culture cell molecular biology

Molecular Biology
The Scientist Staff | Oct 11, 1992 | 2 min read
A. Kakizuka, W.H. Miller, K. Umesono, R.P. Warrell, et al., "Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR with a novel putative transcription factor, PML," Cell, 66:663-74, 1991. Akira Kakizuka (The Salk Institute, La Jolla, Calif.): "Our paper described the genes located at each of the breakpoints of the t(15;17) translocation associated with human acute promyelocytic leukemia (APL). In addition to the karyotype abnormality, the patients with APL can be i
Leukemia and Cancer Stem Cells
Irving Weissman and Michael Clarke | Apr 1, 2006 | 4 min read
FEATUREThe Ecology of Tumors Leukemia and Cancer Stem Cells BY IRVING WEISSMAN AND MICHAEL CLARKECancers and normal tissue stem cells have much in common: Both have self-renewal capacity, and both develop into differentiated progeny. But do true cancer stem cells exist? We believe that they do and that this realization will have a major impact on the understanding and treatment of cancers. Putative cancer stem cells can be recognized by three attr
Scientists Successfully Transplant Human Leukemia Cells into Mice
Diana Kwon | Apr 1, 2017 | 2 min read
While studying the progression of healthy cells into cancerous ones, researchers discover a way to engraft human blood cells into animals.
A rendering of a human brain in blue on a dark background with blue and white lines surrounding the brain to represent the construction of new connections in the brain.
Defying Dogma: Decentralized Translation in Neurons
Danielle Gerhard, PhD | Sep 8, 2023 | 10+ min read
To understand how memories are formed and maintained, neuroscientists travel far beyond the cell body in search of answers.
Molecular Biology Reagent Kits Simplify Lab Procedures
Ricki Lewis | Feb 7, 1993 | 8 min read
Companies discussed in the accompanying article: Bio-Rad Laboratories 2000 Alfred Nobel Dr. Hercules, Calif. 94547 (800) 4 - BIORAD Fax: (800) 879-2289 Products: Call for catalog BIO 101 Inc. 1060 Joshua Way Vista, Calif. 92083 (800) 424-6101 Fax: (619) 598-0116 Products: phage DNA isolation yeast transformation Geneclean DNA purification Mermaid oligomer purification RNaid RNA purification Circleprep plasmid preparation G nome DNA isolation, for genomic DNA BioWhittaker Inc. 8830 Biggs F
Are Cancer Stem Cells Ready for Prime Time?
Suling Liu, Hasan Korkaya, and Max S. Wicha | Apr 1, 2012 | 10+ min read
A flood of new discoveries has refined our definition of cancer stem cells. Now it’s up to human clinical trials to test if they can make a difference in patients.
Cracking Down on Cancer: A Profile of Owen Witte
Diana Kwon | Apr 1, 2020 | 9 min read
Through his studies on cancer-causing viruses, the University of California, Los Angeles, professor has helped develop lifesaving treatments.
The Breakthrough Prize ?Trophy
2024 Breakthrough Prizes in Life Sciences
Danielle Gerhard, PhD | Sep 14, 2023 | 10 min read
This year’s Breakthrough Prizes honor advances in CAR T cancer therapies, cystic fibrosis, and Parkinson’s disease.
Telomeres in Disease
Rodrigo Calado and Neal Young | May 1, 2012 | 10+ min read
Telomeres have been linked to numerous diseases over the years, but how exactly short telomeres cause diseases and how medicine can prevent telomere erosion are still up for debate.
DNA Chips Enlist in War on Cancer
Douglas Steinberg | Feb 20, 2000 | 10+ min read
Graphic: Cathleen Heard The boy had the classic symptoms of acute leukemia--low blood counts and tumor cells circulating in his bloodstream. But the diagnosis was tentative because the tumor cells looked atypical for leukemia. So doctors extracted RNA from the cells, made cDNAs from the RNA, and incubated the cDNAs with a chip bearing thousands of single-stranded gene fragments on its glass surface. The hybridization pattern suggested, surprisingly, that the boy had a muscle tumor. After confirm

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