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Now that the structure of the N-terminal domain of exotoxin S has been revealed, perhaps a drug target will present itself.

Data derived from the Science Watch/Hot Papers database and the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. Pseudomonas aeruginosa gets around. The bacterium thrives in soil and marshes, on marine coasts, and in plant and animal tissues. Of particular interest is its occasional, but often devastating, inhabitation of the human environment. It is an important cause of bacteremia associated with bur

Pseudomonas aeruginosa grows as biofilms in the lungs of patients with cystic fibrosis (CF) but it remains unclear if the bacteria persist because the biofilms are antibiotic-resistant or if resistant variants are selected by antimicrobial therapy itself. In April 18 Nature, Eliana Drenkard and Frederick Ausubel of Harvard Medical School show that Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation and are switched on together.Drenkard & Ausubel observe

Scientists identify the coordinated sequence of pili movements that Pseudomonas aeruginosa use to move.

A compound produced by Pseudomonas aeruginosa activates signaling pathways that prevent seeds from growing in unfavorable environments.

Mice receiving the treatment produced their own monoclonal antibodies and survived infection with the life-threatening pathogen Pseudomonas aeruginosa.

The bacterium Pseudomonas aeruginosa infects burn wounds and forms immune-resistant biofilms like the one shown here, in vitro.

Researchers design a synthetic bacterium that kills the infectious microbe Pseudomonas aeruginosa, sacrificing itself in the process.

Extracellular DNA (yellow) helps regulate movement and prevent traffic jams as bacterial biofilms of Pseudomonas aeruginosa (blue) expand.

Pseudomonas aeruginosa gather swarming speed at the expense of their ability to form biofilms in an experimental evolution setup.