Interdisciplinary Research

These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool http://www.facultyof1000.com.N. Touret et al., "Quantitative and dynamic assessment of the contribution of the ER to phagosome formation,"

December 5, 2005

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These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool http://www.facultyof1000.com.

N. Touret et al., "Quantitative and dynamic assessment of the contribution of the ER to phagosome formation," Cell, 123:157–170, Oct. 7, 2005.

Aligning an impressive array of methods, this study provides strong evidence against the recently proposed model of a significant contribution of endoplasmic reticulum (ER) membranes during early phagosome biogenesis. Quantitative approaches are used to demonstrate that ER membrane components are absent from phagosomes both in macrophages and dendritic cells, while an early and substantial contribution of endosomal membranes is readily detected.

Peter Van EndertNational Institute for Medical Research Safety (INSERM), France

D.T. Nair et al., "Rev1 employs a novel mechanism of DNA synthesis using a protein template,"Science, 309:2219–22, Sept. 30, 2005.

This article reports the fascinating finding that Rev1, a member of the translesion synthesis family of DNA polymerases, utilizes a novel mechanism of nucleotide incorporation that involves pairing of the incoming nucleotide (deoxycytidine triphosphate) with a Rev1 amino acid residue rather than the canonical base-base pairing.

Lucio ComaiUniversity of Southern California

M.R. Macbeth et al., "Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing," Science, 309:1534–9, Sept. 2, 2005.

This work reports the fascinating but surprising finding that the RNA editing enzyme ADAR2 requires soluble inositol hexakisphosphate binding for function and, potentially, structural integrity. There have been several recent reports of inositol hexa-kisphosphate influencing cellular and enzyme activities ... This study directly suggests a mechanism by which the inositide is required for activity.

Susan WenteVanderbilt University

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