Interfering nonsense

Worm proteins required for nonsense-mediated mRNA decay are also required for maintenance of RNA interference.

By | September 18, 2000

In RNA interference (RNAi), introduced double-stranded RNA (dsRNA) triggers gene-specific silencing by inducing mRNA degradation. Domeier et al. report in the 15 September Science that some of the worm SMG proteins, which are required for nonsense-mediated mRNA decay, are also required for maintenance of RNAi (Science 2000, 289:1928-1930). RNAi is initiated in the smg mutants as normal, but the animals subsequently recover. SMG proteins may be involved in an amplification step of RNAi. The proteins' possible cleavage or dsRNA-unwinding activities could provide templates for an RNA-directed RNA polymerase.

Popular Now

  1. That Other CRISPR Patent Dispute
    Daily News That Other CRISPR Patent Dispute

    The Broad Institute and Rockefeller University disagree over which scientists should be named as inventors on certain patents involving the gene-editing technology.

  2. How Gaining and Losing Weight Affects the Body
    Daily News How Gaining and Losing Weight Affects the Body

    Millions of measurements from 23 people who consumed extra calories every day for a month reveal changes in proteins, metabolites, and gut microbiota that accompany shifts in body mass.

  3. Neurons Use Virus-Like Proteins to Transmit Information
  4. DOE-Sponsored Oak Ridge National Laboratory to Cut 100 More Jobs
AAAS