Hungry yeast live longer

Caloric restriction (CR) is known to extend life-span in many species, and is thought to work by slowing metabolism and thus the generation of toxic reactive oxygen species. In the 22 September Science Lin et al. report that yeast also grow longer under conditions of CR (Science 2000, 289:2126-2128). Yeast on low-glucose plates, or with a defect in the glucose-activated protein kinase A (PKA) pathway, divide for more generations before senescing. The histone deacetylase and silencing protein Sir

By | September 25, 2000

Caloric restriction (CR) is known to extend life-span in many species, and is thought to work by slowing metabolism and thus the generation of toxic reactive oxygen species. In the 22 September Science Lin et al. report that yeast also grow longer under conditions of CR (Science 2000, 289:2126-2128). Yeast on low-glucose plates, or with a defect in the glucose-activated protein kinase A (PKA) pathway, divide for more generations before senescing. The histone deacetylase and silencing protein Sir2p is known to affect aging, and is required for the CR effect. Maintenance of silencing may be critical to longevity in many species, either by repressing genomic instability or by preventing inappropriate gene expression.

Popular Now

  1. Thousands of Mutations Accumulate in the Human Brain Over a Lifetime
  2. Two Dozen House Republicans Do an About-Face on Tuition Tax
  3. 2017 Top 10 Innovations
    Features 2017 Top 10 Innovations

    From single-cell analysis to whole-genome sequencing, this year’s best new products shine on many levels.

  4. The Biggest DNA Origami Structures Yet
    Daily News The Biggest DNA Origami Structures Yet

    Three new strategies for using DNA to generate large, self-assembling shapes create everything from a nanoscale teddy bear to a nanoscale Mona Lisa.

FreeShip