PAPERS TO WATCH

I. Coppens et al.," Toxoplasma gondii sequesters lysosomes from mammalian hosts in the vacuolar space,"

July 1, 2006

I. Coppens et al.," Toxoplasma gondii sequesters lysosomes from mammalian hosts in the vacuolar space," Cell , 125:261-74, April 21, 2006.

This outstanding paper shows that the intracellular protozoan Toxoplasma gondii exploits host microtubules to recruit and sequester host lysosomes into the parasitophorous vacuole. Through this process, the parasite gains access to host organelles that can provide a source of low-molecular-weight nutrients.

Eric Denkers
Cornell University, USA

V.N. Ngo et al., "A loss-of-function RNA interference screen for molecular targets in cancer," Nature , 441:106-10, May 4, 2006.

An elegant combination of bar-coding and inducible vector is used to express and detect small hairpin RNAs that target genes required for specific functions. Done systematically, it opens the way to a differential functional profiling of cells in health and disease.

Giulio Superti-Furga
Austrian Academy of Sciences, Austria

D.Y. Coudreuse et al., "Wnt gradient formation requires retromer function in Wnt-producing cells," Science , 312:921-4, May 12, 2006.

Wnt proteins function as morphogens to form long-range gradients to pattern developing tissues in animals. The authors report that the endosome to Golgi "retromer" vesicle trafficking complex, first characterized in yeast, is involved in long-range signaling of the C. elegans Wnt ortholog EGL-20.

Tom Stevens
University of Oregon, USA

These papers were selected from multiple disciplines from the Faculty of 1000, a web-based literature awareness tool (www.f1000biology.com).

1. C. Berthet et al., "Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation," Dev Cell, 10:563-73, May 2006.

Popular Now

  1. That Other CRISPR Patent Dispute
    Daily News That Other CRISPR Patent Dispute

    The Broad Institute and Rockefeller University disagree over which scientists should be named as inventors on certain patents involving the gene-editing technology.

  2. How Gaining and Losing Weight Affects the Body
    Daily News How Gaining and Losing Weight Affects the Body

    Millions of measurements from 23 people who consumed extra calories every day for a month reveal changes in proteins, metabolites, and gut microbiota that accompany shifts in body mass.

  3. Neurons Use Virus-Like Proteins to Transmit Information
  4. DOE-Sponsored Oak Ridge National Laboratory to Cut 100 More Jobs
AAAS