FDA approves second novel HIV drug

Till recently, just two classes of antiretroviral drugs, reverse transcriptase inhibitors and protease inhibitors, were on the market to treat HIV infection. Last week, the FDA linkurl:approved;http://www.reuters.com/article/health-SP/idUSN1221331120071015 Merck's raltegravir (Isentress), which interferes with viral replication at a different point, blocking the enzyme integrase to prevent the integration of the viral genetic material into host DNA. In our September issue, The Scientist reporte

By | October 16, 2007

Till recently, just two classes of antiretroviral drugs, reverse transcriptase inhibitors and protease inhibitors, were on the market to treat HIV infection. Last week, the FDA linkurl:approved;http://www.reuters.com/article/health-SP/idUSN1221331120071015 Merck's raltegravir (Isentress), which interferes with viral replication at a different point, blocking the enzyme integrase to prevent the integration of the viral genetic material into host DNA. In our September issue, The Scientist reported on Pfizer's linkurl:maraviroc,;https://www.the-scientist.com/2007/9/1/43/1/ approved in the US in August under the brand name Selzentry. While other HIV drugs work inside the cell, maraviroc blocks the activity of CCR5, the coreceptor on the cell surface that facilities HIV's entry into the cell. The two are the first compounds with a novel mechanism of action against the virus to be approved in several years. So far, both drugs are approved for use only in patients who have developed a resistance to other drugs.

Popular Now

  1. 2017 Top 10 Innovations
    Features 2017 Top 10 Innovations

    From single-cell analysis to whole-genome sequencing, this year’s best new products shine on many levels.

  2. Thousands of Mutations Accumulate in the Human Brain Over a Lifetime
  3. Antiviral Immunotherapy Comes of Age
    News Analysis Antiviral Immunotherapy Comes of Age

    T-cell therapies are not just for cancer. Researchers are also advancing immunotherapy methods to protect bone marrow transplant patients from viral infections. 

  4. Search for Life on the Red Planet
FreeShip