Weight loss drugs scrapped

Sanofi-Aventis announced this week that it would discontinue clinical trials of its anti-obesity drug, Acomplia. The decision followed similar moves by Pfizer and Merck, who also recently abandoned development of similar weight loss drugs. Why is everyone jumping ship? The drugs all target the cannabinoid receptor CB1 -- also the target receptor for marijuana - in order to suppress appetite (read how Acomplia's mechanism of action compares with other diet drugs linkurl:here).;http://www.the-sc

By | November 7, 2008

Sanofi-Aventis announced this week that it would discontinue clinical trials of its anti-obesity drug, Acomplia. The decision followed similar moves by Pfizer and Merck, who also recently abandoned development of similar weight loss drugs. Why is everyone jumping ship? The drugs all target the cannabinoid receptor CB1 -- also the target receptor for marijuana - in order to suppress appetite (read how Acomplia's mechanism of action compares with other diet drugs linkurl:here).;https://www.the-scientist.com/2008/6/1/40/100/ However, the drugs have been under mounting scrutiny by regulatory entities in the US and Europe for increasing the risk of depression and suicidal thoughts. Acomplia has been sold in Europe since 2006, but last month the company stopped marketing the drug there after the EMEA -- Europe's version of the FDA -- said the risks to patients outweighed the benefits, according to the linkurl:__Wall Street Journal.__;http://blogs.wsj.com/health/2008/11/06/pfizer-sanofi-aventis-abandon-obesity-drugs/ In a linkurl:statement;https://www.the-scientist.com/2008/6/1/40/100/ released this week, Pfizer said that its decision to stop development was based on "changing regulatory perspectives on the risk/benefit profile of the CB1 class," of drugs. The FDA has never granted approval to any diet drugs in this class.

Popular Now

  1. 2017 Top 10 Innovations
    Features 2017 Top 10 Innovations

    From single-cell analysis to whole-genome sequencing, this year’s best new products shine on many levels.

  2. Thousands of Mutations Accumulate in the Human Brain Over a Lifetime
  3. Antiviral Immunotherapy Comes of Age
    News Analysis Antiviral Immunotherapy Comes of Age

    T-cell therapies are not just for cancer. Researchers are also advancing immunotherapy methods to protect bone marrow transplant patients from viral infections. 

  4. The Rising Research Profile of 23andMe
    News Analysis The Rising Research Profile of 23andMe

    An exploration of the genetics of earlobe attachment is just the latest collaborative research project to come out of the personal genetic testing company.

FreeShip