Top 7 genetics papers

A snapshot of the highest-ranked articles in genetics and related areas in the past 30 days

By | November 2, 2010

linkurl:1. Mapping transcriptomes; While mapping every transcriptional start site and operon of Helicobacter pylori at single-nucleotide resolution, the authors identify novel small RNAs, reveal the widespread nature of antisense transcription, and unveil a new technique to investigate the genomic complexities of other important pathogens, such as Salmonella and Mycobacterium tuberculosis. CM Sharma et al, linkurl:Nature,; 464:250-5, 2010. Evaluated by N. Ahmed, Institute of Life Sciences, India; M. Hensel, Friedrich-Alexander University Erlangen-Nuremberg (FAU); S. Ho Sui and F. Brinkman, Simon Fraser University; S. Vogt and T. Raivio, University of Alberta; A. Danielli and V. Scarlato, University of Bologna. linkurl:Free F1000 Evaluation;
Image: Wikimedia commons, Zephyris
linkurl:2. Epigenetics in mind; The body's tendency to silence the expression of one parental allele in favor of the other -- a phenomenon known as genomic imprinting -- is much more widespread in the brain than scientists have believed, according to a new genome-wide study in mice. Surprisingly, more than 1300 genes expressed in the mouse brain appear to exhibit "parent-of-origin" epigenetic effects. C. Gregg, et al., linkurl:Science,; 329:643-8, 2010. Evaluations by R. Sapolsky, Stanford University; ME Carter and L. de Lecea, Stanford University; J. Messing, Rutgers University; Y Ikeuchi and A Bonni, Harvard Medical School; D Sweatt, University of Alabama at Birmingham. linkurl:Free F1000 Evaluation; linkurl:3. Translation goes local; Protein synthesis is a complicated game, but for the first time researchers have shown direct interaction between a transmembrane receptor, called DCC, and the translational machinery in rodent neurons, a step that likely facilitates localized protein production. J. Tcherkezian, et al., linkurl:Cell,; 141:632-44, 2010. Evaluations by K Kwan and CB Chien, University of Utah; J Heraud and M Kiebler, Center for Brain Research, Medical University of Vienna, Austria; W Kroeze and B Roth, University of North Carolina; L Desgroseillers, University of Montreal, Canada; L Columbus, University of Virginia. linkurl:Free F1000 Evaluation; linkurl:4. No RNA "dark matter"?; Most of the DNA that's transcribed into RNA in fact codes for proteins, a finding that disputes previous studies that suggested that the majority of mammalian transcripts are non-coding "dark matter." H. van Bakel et al. linkurl:PLoS Biol,; May; 8(5):e1000371, 2010. A Siepel, Cornell University; S Macdonald, University of Kansas; A Sellam and A Nantel, National Research Council of Canada; D Reines, Emory University School of Medicine. linkurl:Free F1000 Evaluation; linkurl:5. Super E. Coli; The mother cell of E. coli maintains a constant growth rate throughout its replicative life (hundreds of cell divisions), despite accumulating damage and an increased probability of death, suggesting that growth and aging are decoupled, unlike all other studied aging models. P. Wang et al., linkurl:Curr Biol,; 2010 May 26, 20:1099?1103. Evaluated by R Kishony, Harvard University; T Meier, Max Planck Inst Biophysics; Yves Barral, ETH. linkurl:Free F1000 Evaluation; linkurl:6. How autophagosomes form; Under conditions of starvation, autophagosomes form to resupply the cell by bringing nutrients from the cytosol or other organelles to the lysosomes, ensuring the cell's survival. New findings reveal an essential ingredient to this mysterious process: the outer membrane of mitochondria. DW Hailey et al. linkurl:Cell,; 141:656-67, 2010. Evaluated by R Gross, University of Wuerzburg, Germany; M Markaki and N Tavernarakis, Foundation for Research and Technology-Hellas, Greece; Y Xiang and Y Wang, University of Michigan, E Lau and Z Ronai, The Burnham Institute. linkurl:Free F1000 evaluation; linkurl:7. New tumor targets?; A scan of 1800 megabases of DNA from 441 tumors reveals more than 2500 somatic mutations, providing the mutation "spectra" for cancers, including protein kinases and G-protein-coupled receptors, some of which may serve as druggable targets. Z. Kan et al, linkurl:Nature,; 466:869-73, 2010. Evaluated by T Ried, National Cancer Institute; D Nierlich, University of California, Los Angeles; S Gutkind, National Institute of Dental and Craniofacial Research. linkurl:Free F1000 evaluation; The F1000 Top 7 is a snapshot of the highest ranked articles from a 30-day period on Faculty of 1000 Genomics & Genetics, as calculated on October 28, 2010. Faculty Members evaluate and rate the most important papers in their field. To see the latest rankings, search the database, and read daily evaluations, visit linkurl:;
**__Related stories:__***linkurl:Top 7 hidden jewels;
[26th October 2010] *linkurl:Top 7 papers in biochemistry;
[19th October 2010] *linkurl:Top 7 papers in neuroscience;
[12th October 2010]


Avatar of: Dov Henis

Dov Henis

Posts: 97

November 9, 2010

Probing Human Genetic Diversity\n\n"1000 Genomes pilot a hit with geneticists"\nThe first stage of a project to probe human genetic diversity has found millions of new variations.\n\n\nFor probing human DNA genetic diversity bear in mind that:\n\n"PERO SE MOVERA \nEARTH LIFE HAS ALWAYS BEEN AND STILL IS AN RNA WORLD"\n\n\nA. Enzymes Exposed \nClearer views of the cell?s movers and shakers threaten a century-old mainstay of biology \n \n\nB. EHRC \n \n\nC. It's not the protein that makes the enzyme. It's the RNA that has evolved the protein. And it's the RNAs that have evolved and produce and employ the DNA templates to carry out their life processes, for enhancing Earth's biosphere, for enhancing and constraining as long as possible some of the energy destined to fuel the ongoing cosmic expansion. \n\nScience should adjust its vision, comprehension and conception. \n\nIT HAS ALWAYS BEEN AND IT STILL IS AN RNA EARTH LIFE. \n\n\nDov Henis \n(Comments From The 22nd Century) \n\n\nSeed of Human-Chimp Genomes Diversity\n \n03.2010 Updated Life Manifest \n \nCosmic Evolution Simplified \n \nGravity Is The Monotheism Of The Cosmos \n \nEvolution, Natural Selection, Derive From Cosmic Expansion\n

Popular Now

  1. Thousands of Mutations Accumulate in the Human Brain Over a Lifetime
  2. Can Young Stem Cells Make Older People Stronger?
  3. Two Dozen House Republicans Do an About-Face on Tuition Tax
  4. Insects’ Neural Learning and Memory Center Discovered in Crustaceans