Top 7 in oncology

A snapshot of the most highly ranked articles in oncology, from Faculty of 1000

By | April 12, 2011

linkurl:1. Donor match not needed; Elderly acute myeloid leukemia patients who received blood stem cells from non-matching donors after chemotherapy showed marked improvement over patients receiving chemo alone. M. Guo et al., "Infusion of HLA-mismatched peripheral blood stem cells improves the outcome of chemotherapy for acute myeloid leukemia in elderly patients," linkurl:__Blood,__; 117:936-41, 2011. Evaluated by Arati Rao, Duke Univ; Riccardo Varaldo, U of Genova and S Martino Hosp, Italy; Nelson Chao, Duke Univ Med Cntr. linkurl:Free F1000 Evaluation; linkurl:2. Weighing brain radiation therapy; Clinicians have debated whether whole-brain radiation therapy (WBRT) is the appropriate follow-up therapy for CNS lymphoma, a cancer of the immune cells in the brain, because of its relatively high risk of toxicity. A clinical trial suggested that WBRT should not be given to patients who respond well to methotrexate, a first-line drug against the disease, but might improve overall survival for those who don't, though the results lacked statistical significance. E. Thiel et al., High-dose methotrexate with or without whole brain radiotherapy for primary CNS lymphoma (G-PCNSL-SG-1): a phase 3, randomised, non-inferiority trial," linkurl:__Lancet Oncol,__; 11:1036-47, 2010. Evaluated by Priya Kumthekar and Jeffrey Raizer, Northwestern Univ; Roger Abounader and David Schiff, U of Virginia Neuro-Oncology Cntr. linkurl:Free F1000 Evaluation;
Leukemia cells
Image: Wikimedia/ PLoS Biol
linkurl:3. Estimating breast cancer survival; Researchers compiled data from more than 13,000 women with metastatic breast cancer in order to provide patients a more detailed answer about their chances of survival, and to provide clinicians with a guide on how to communicate the information. B.E. Kiely et al., "How long have I got? Estimating typical, best-case, and worst-case scenarios for patients starting first-line chemotherapy for metastatic breast cancer: a systematic review of recent randomized trials," linkurl:__J Clin Oncol,__; 29:456-63, 2011. Evaluated by Michael Fisch, U of Texas, MD Anderson Cancer Cntr. linkurl:Free F1000 Evaluation; linkurl:4. Details improve prognosis estimates; Because mammography can detect breast tumors earlier than other detection means and can give clinicians more precise information, patients whose tumors were identified with mammograms had increased survival. The results suggest that how a cancer is detected should be factored in when communicating the certainty of a prognosis. S. Mook et al., "Independent Prognostic Value of Screen Detection in Invasive Breast Cancer," linkurl:__J Natl Cancer Inst,__; 103:585-97, 2011. Evaluated by Alberto Quaglia National Cancer Res Inst, Italy. linkurl:Free F1000 Evaluation; linkurl:5. The genetics of a germline cancer; Researchers honed the genetic basis of multiple endocrine neoplasia type 2, a hereditary cancer involving the gene RET. The data may help clinicians stratify patients into different groups based on type of RET mutation, which could influence treatment decisions. K. Frank-Raue et al., "Risk profiles and penetrance estimations in multiple endocrine neoplasia type 2A caused by germline RET mutations located in exon 10," linkurl:__Hum Mutat,__; 32:51-58, 2011. Evaluated by Rute Tomaz, Jaime Miguel Gomes Pita and Branca Cavaco, Inst Portugues de Oncologia de Lisboa, Portugal. linkurl:Free F1000 Evaluation; linkurl:6. Kill all tumor cells; Patient leukemias transplanted into mice reveal that not only will the most aggressive cells within a tumor cause disease, but less aggressive and genetically distinct cells may also increase in number and cause disease, suggesting that therapies should aim to eradicate all tumor cells, not just the prevailing clone. F. Notta et al., "Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells," linkurl:__Nature__; 469:362-67, 2011. Evaluated by Anil Sadarangani and Catriona Jamieson, UCSD. linkurl:Free F1000 Evaluation; linkurl:7. Microtubule inhibitors extend survival; Microtubule deregulation is one of the hallmarks of cancer cells, whose cytoplasms become overrun with filaments. Patients with metastatic breast cancer have about a 3-month increase in patient survival when treated with the microtubule inhibitor, eribulin, which initiates cancer cell death by blocking cell division J. Cortes et al., "Eribulin monotherapy versus treatment of physician's choice in patients with metastatic breast cancer (EMBRACE): a phase 3 open-label randomised study," linkurl:__Lancet__; 377:914-23, 2011. Evaluated by Blair Irwin and Jeffrey Peppercorn, Duke Univ. linkurl:Free F1000 Evaluation; The F1000 Top 7 is a snapshot of the highest ranked articles from a 30-day period on Faculty of 1000 in Oncology, as calculated on April 7, 2011. Faculty Members evaluate and rate the most important papers in their field. To see the latest rankings, search the database, and read daily evaluations, visit linkurl:;
**__Related stories:__***linkurl:Top 7 in cancer biology;
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