Stem cells may mend liver damage

Researchers have found a way to reprogram cells from mouse tails to behave like mature liver cells, which appear to be able to repair damaged livers.

By | May 14, 2011

Fatty liver diseaseNEPHRON / WIKIPEDIA

Researchers have found a way to reprogram cells from mouse tails to behave like mature liver cells, which appear to be able to repair damaged livers, according to a study published this week in Nature. The paper is proof of the concept that reprogrammed cells can skip the pluripotency stage and still hold therapeutic value. Cell biologist Lijian Hui of the Shanghai Institute for Biological Sciences in China and his colleagues expressed three proteins, and suppressed one, to reprogram fibroblasts from mouse tails into liver-like cells, which they then transplanted into mutant mice that were unable to detoxify certain metabolic intermediates. Five of the 12 animals that received the engineered cells survived, while all control animals died.

"It's really exciting," Paul Gadue, a stem-cell biologist at the Children's Hospital of Philadelphia in Pennsylvania who was not involved in the study, told Nature. "If this work could be translated to humans, it could be very powerful."

Add a Comment

Avatar of: You

You

Processing...
Processing...

Sign In with your LabX Media Group Passport to leave a comment

Not a member? Register Now!

LabX Media Group Passport Logo

Popular Now

  1. Thousands of Mutations Accumulate in the Human Brain Over a Lifetime
  2. 2017 Top 10 Innovations
    Features 2017 Top 10 Innovations

    From single-cell analysis to whole-genome sequencing, this year’s best new products shine on many levels.

  3. Search for Life on the Red Planet
  4. Two Dozen House Republicans Do an About-Face on Tuition Tax
FreeShip