HIV Prevention Debate

The suggested approval of a widely used antiretroviral drug to prevent HIV transmission in uninfected people sparks a debate about the possible dangers of such a move.

By Cristina Luiggi | May 21, 2012

Scanning electron micrograph of HIV-1 budding (in green) from cultured lymphocyte WIKIMEDIA COMMONS, CDC-C. GOLDSMITH

Earlier this month, an advisory panel for the US Food and Drug Administration (FDA) recommended the approval of the widely used antiretroviral drug Truvada for the prevention of HIV transmission. Although clinical trials of Truvada have demonstrated a 90 percent efficacy in preventing the sexual transmission of HIV when taken daily, ScienceNOW reported, the panel’s decision to approve the drug for use in uninfected people was met with considerable resistance by experts who worry that incorrect use of the drug will lead to risky behavior as well as widespread drug resistance.

"I think it will be a catastrophe for HIV prevention in this country," Michael Weinstein, president of the AIDS Healthcare Foundation and the most vocal opponent of the recent decision, told ABC News. "Men don't need more excuses not to use condoms."

Health officials also worry that failure of people to adhere to the once-daily dose of Truvada will not only result in a lower drug efficacy, but it could lead to massive drug resistance. Nevertheless, others saw the decision in more positive light. “The meeting and vote represent a tremendous milestone for HIV prevention,” Jared Baeten, an epidemiologist at the University of Washington, Seattle, told ScienceNOW.

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Avatar of: Dov


Posts: 1457

May 22, 2012

Understand why and how...

SIV-HIV And Human Y Lessons
Natural SIV Hosts: Showing AIDS the Door
The case of Human Y applies clearly to SIV-HIV and to many other cases:
Primates have been, and continue, evolving immunity defenses by ongoing physiological reactions-adaptation to changing circumstances, whereas humans rely ONLY on changing the causative circumstances.  In the immunization development field the RNA nucleotide genes are far more experienced and successful than we humans…
Genes and genomes are BOTH ORGANISMS. Their genetic expressions evolve with, and are set by, the cultural circumstances in accordance with the RNAs-genes-organisms, natural selection. This is Darwinian evolution, extended backward – as it should be – to our primal constitutional organisms.
Rash Human Y Demising?
On The Male Sex Chromosome
(posted July 25 2009)
A. On Human male sex chromosome, again?
From “Male Sex Chromosome Losing Genes By Rapid Evolution, Study Revealsâ€쳌
“…we also know that most of the genes were not important for survival because they were lost, which led to the very different numbers of genes we observe between the once-identical X and Y. Although there is evidence that the Y chromosome is still degrading, some of the surviving genes on the Y chromosome may be essential, which can be inferred because these genes have been maintained for so long.â€쳌
“…found evidence that some others are on track to disappear, as well.â€쳌
B. “Spontaneous speciation?â€쳌
“Conservation of Y-linked genes during human evolution revealed by comparative sequencing in chimpanzeeâ€쳌
Chimp’s genome has been continuing survival by physiologically adapting to changing environments, whereas Human’s genome continues survival mainly by modifying-controlling its environment.
C. AcademEnglish verbiage should be at least scientifically careful
The rate of “losing genesâ€쳌 by an organism is not a constant value of a natural law. It is induced and set mostly by the rate and nature of the change of culture of the organism, which is induced, in turn , by various circumstantial factors…
IMO we can feel assured that the human Y is not on an accelerating course to oblivion…
Dov Henis
(Comments from 22nd century)
21st century science whence and whither
Earth life genesis from aromaticity-H bonding
Seed of human-chimp genome diversity

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