Researchers use DNA origami to generate tiny mechanical devices that deliver a drug that cuts off the blood supply to tumors in mice.
Publicly accessible databases now store nearly 1 million gene-expression datasets, giving researchers a robust resource for discovery.
July 23, 2012|
With more and more researchers conducting experiments that tease apart the functions of the thousands of genes that make up the genomes of mice, rats, and humans, the number of gene-expression datasets deposited in publicly accessible databases will soon reach 1,000,000, according to an analysis done by Nature. Adding together the number of datasets in the two major public data repositories, the National Center for Biotechnology Information's Gene Expression Omnibus and the gene-expression database at the European Bioinformatics Institute, the milestone should be reached within the next month.
"Some time in the next few weeks, the number of deposited data sets will top one million," Monya Baker wrote in Nature last week.
Gene-expression data can help scientists test preliminary hypotheses about which genes may contribute to the development of certain diseases, leading to potential drug targets. For example, a researcher could comb public data from several studies of people or animal models with Alzheimer's disease to determine which gene or genes are highly expressed. After identifying likely suspects, she could then perform wet lab experiments that further tease apart the roles of those genes in her own study subjects. If one gene emerges as a key driver of the disease, drugs can be developed to target the functioning of that gene with the hope that it may change the course of the disease. Having a robust database at the outset saves time and money in targeting the genes most likely to impact a particular disease. And more data equals a better chance of successfully identifying a key player in disease progression.
July 23, 2012
And what about when this sort of technology and information gets into the wrong hands? What about designer babies, artificial selection, pressurized breeding towards certain traits until what's left is no longer human? It will be so tempting for some people, and they will have such a lack of ethical or evolutionary reasoning, and all that needs to occur is a fraction of people do it and the others will cross breed with them over time. I am really afraid that humans as we now know them are not going to exist for much longer, while superficial, nonsensical and indefensible ideas of "improvement" (larger brains, being taller, less need of sleep, etc.)... are going to drive humanity into a pathological and crazy gene soup mess culminating in humanity ceasing to exist.
July 23, 2012
The only correct way to measure gene expression is measure the number of mRNA molecules per cell (not per DNA, or rRNA, or tissue/cell wet weight) any other approach is incorrect and totally misleading. Somebody has to analyze this myriad (~1 million of deposits) critically before the databases will become operational, otherwise an enormous avalanche of mistakes and misconceptions will flood the field/literature. Michael Lerman, Â M.D., Ph.D.