MIT Lab Retracts Paper

A paper describing a new method for imaging synapse formation has been retracted after it emerged that the first author falsified data to prove its effectiveness.

By | February 15, 2013

WIKIMEDIA, STEAKPINBALLA well-respected biochemist and rising star at the Massachusetts Institute of Technology (MIT) has retracted an important paper after an internal investigation found that her former postdoc faked the figures, reported Retraction Watch.

Alice Ting, named one of Technology Review’s “Innovators Under 35” in 2006, published the paper in question—which demonstrated a new way to image the mechanisms of synapse formation in the brain—in Cell in 2010. The first author was postdoc Amar Thyagarajan.

The paper was well-received, and Autism Speaks, which funded Thyagarajan’s postdoc, declared that “the ability to observe the active development of synapses will undoubtedly factor into future discoveries, paying dividends for some time to come.” The paper has since been cited 17 times, according to ISI Web of Knowledge

But yesterday (February 14), Cell retracted the paper. The accompanying notice explained that when Ting’s group discovered they could not reproduce the results, MIT started an investigation. Detailing the findings of that investigation in a letter to Cell, Claude Canizares, vice president for research and associate provost at MIT, stated that: “MIT found that the first author, Dr. Thyagarajan, falsified or fabricated figures in this publication. MIT’s investigation also found that Dr. Thyagarajan was solely responsible for the scientific misconduct that resulted in the falsified or fabricated data.”

The retraction notice was not signed by Thyagarajan—who is now a technology specialist at Clark + Elbing, a patent law firm in Boston, according to Retraction Watch. Indeed, Thyagarajan responded with an email to Retraction Watch to say that he stands by the results, and that the retraction was carried out despite his objections.

“The findings against me were the result of a deeply flawed and sloppy investigation that ignored evidence that someone had tampered with and deleted my data, after the publication of the paper, and made it look as if I had falsified data,” he wrote. “The matter is now at ORI [the Office of Research Integrity]. I expect to have a full and fair opportunity to be heard before impartial fact-finders and am confident that my innocence will be established.”

For her part, Ting pointed out that her lab has subsequently found that, with modified constructs and protocols, the method in question can be used to do what was originally claimed in the retracted paper. She plans to report her new findings in a future publication.

Add a Comment

Avatar of: You



Sign In with your LabX Media Group Passport to leave a comment

Not a member? Register Now!

LabX Media Group Passport Logo


Avatar of: Paul Stein

Paul Stein

Posts: 237

February 18, 2013

Why is it that fraudsters seem to gravitate towards lawyers in the end?

Just wondering.

Popular Now

  1. A Newly Identified Species Represents Its Own Eukaryotic Lineage
  2. Telomere Length and Childhood Stress Don’t Always Correlate
  3. Optogenetic Therapies Move Closer to Clinical Use
  4. Research Links Gut Health to Neurodegeneration
    The Nutshell Research Links Gut Health to Neurodegeneration

    Rodent studies presented at the Society for Neuroscience meeting this week tie pathologies in the gastrointestinal tract or microbiome composition with Parkinson’s and Alzheimer’s diseases.