Science on Celluloid

Scientist? Filmmaker? Alexis Gambis welcomes both labels.

By Andrew P. Han | February 28, 2013

Alexis Gambis wants to show the world of science as he sees it.IMAGE BY: CARLOS FUGUETBy now, Alexis Gambis has grown accustomed to the idea of life between two worlds. He spent his childhood ping-ponging between Paris and New York, first for his parents’ education, then his own. “I'm kind of from nowhere,” he says. Currently he traverses the intersection of science and art, a rare combination of both biologist and filmmaker whose works are an original mix of vision and thematic content.

Gambis says he started working in film as something to help him “get through” his Ph.D. research in molecular biology at Rockefeller University in New York City. But it has now become much more. As a grad student Gambis felt increasingly dissatisfied with the stereotypical depictions of scientists in film—too often portrayed as isolated outcasts conducting farfetched and dangerous experiments. So he started making his own films exploring the daily lives of real scientists. To give his hobby a venue, he started a film series that bloomed into the Imagine Science Film Festival, a weeklong affair that launched in 2008. With his doctorate complete, the 31-year-old Gambis is now finishing a Master of Fine Arts at New York University's Tisch School of the Arts and is making a feature film about a sex-crazed geneticist.

Gambis bounces between the worlds of film and science. He has directed James Franco and Mila Kunis, Spike Lee is his thesis advisor. His films are heavily focused on stories and characters, but not at the expense of bringing real science to the screen. Along with using visual aids to help explain the scientific details, he says that he strives to show researchers as complete humans, rather than as deranged individuals, isolated from the rest of society.

Gambis is rerouting his career to filmmaking, but it’s not for a lack of successes in the lab. Under the tutelage of Rockefeller molecular biologist Hermann Steller, Gambis studied how cells are programmed to die, a process that can be either helpful or harmful in different diseases. In cancer, for example, programmed cell death can prevent the spread of tumors, while in Alzheimer’s and other neurodegenerative diseases, the effect is devastating. Gambis’s research focused on the degeneration of nerve cells in the retinas of fruit flies. “Alexis made some very nice discoveries,” Steller says.

For his dissertation, which was featured on the cover of Developmental Biology, Gambis developed an imaging system to visualize nerve cells, allowing him to track their death in living flies and determine which genes were responsible for it. The significance of working on the visual system of the fly, in a visual way, was not lost on Gambis. “In a weird way, it's what got me interested in film,” he says.

But Gambis might also attribute his gravitation to filmmaking to familial influence. His father is a French engineer-turned-painter and his mother is a Venezuelan filmmaker who studied at New York University in the '80s alongside Spike Lee. And as an undergraduate, Gambis studied both film and biology at Bard College in Upstate New York. At the time, he thought he didn't have much to say. That changed when he began his doctorate. “That's when everything that was dormant came back,” he says.

As with all creative endeavors, making films while a science grad student was not easy. Gambis says that Steller was supportive and never criticized or discouraged him (and even lent him lab space to film in). Other scientists, he says, were not so supportive. “They were not exactly understanding when I said I wanted to do film.”

But Gambis does not see a conflict in his decision to pursue a career in filmmaking with science as his muse: “I've never thought about what I did as me leaving.”

Ever ambitious, Gambis has decided to make a feature film for his Master’s thesis, rather than a short film as most students do.

His thesis film, “The Fly Room,” is about Columbia University geneticist Calvin Bridges, who worked under renowned geneticist Thomas Hunt Morgan at Columbia on Drosophila. Bridges’s work was intimately linked to reproduction and aspects of sex and played an important role in developing modern genetics. A different kind of sex was on his mind outside the lab. According to Gambis—who interviewed Bridges’s daughter Betsey extensively for the film—the geneticist was also a womanizer, had an affair with someone in his lab, started a brothel, and eventually died of syphilis.

The film, chronicling a visit Betsey made to the fly room as a young girl, is about discoveries, Gambis says: about science, about sexuality, and about identity. “My films are very much about how the work that scientists do is intimately linked to their daily lives,” he says.

The Imagine Science Film Festival, which will celebrate its sixth annual installment this October, has been instrumental in advancing his vision. “He's given this kind of interdisciplinary work a home it never had before,” says Noah Hutton, a filmmaker with an undergraduate degree in neuroscience. “That's remarkable. That's a forward thinking move he made.”

Gambis‘s latest project is a video blog series entitled “My Mind's Eye,” starring New York University neuroscientist Joseph LeDoux. The filmmaker describes it as a conversation between LeDoux and leading neuroscientists, in the vein of independent filmmaker Jim Jarmusch's collection of narrative vignettes, “Coffee and Cigarettes.”

Gambis’s many commitments—the film festival, his thesis, numerous projects and speaking engagements around the world—sometimes make him seem like a fleeting ghost to those who know him. He was recently in Venezuela shooting a film with his mother, before jetting off to Abu Dhabi, to give a lecture.

“Sometimes I worry he's doing too many things to finish our project,” says LeDoux. “But he doesn't put out stuff of poor quality, so even if it takes longer, I know it will be good.”

This article is provided by Scienceline, a project of New York University's Science, Health and Environmental Reporting Program.

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Avatar of: Ed M.

Ed M.

Posts: 45

March 1, 2013




The living room is half-filled with animal model cages and lab equipment.

Neurochemical innovator PATTON CLARK is working on his doctorate in memory fixing agents and has accidentally discovered the opposite of what he was looking for. 

NOT a way to improve the human memory through a strengthening of the neural pathways for mnemonic storage but something dangerously unexpected that leaves him as a 26 year old de facto infant -after one of his innoculated lab rats bites through his rubber glove and transmits the experimental hippocampus-aimed chemical -which he has injected the rodent with- into his own bloodstream.

His girlfirend AMELIA CHAMBERS knocks on the door, and, getting no answer, opens it and CALLS inside:


      Pat?  You relatively decent? (stepping into the living room)

See spots Patton seated on the floor, leaning against a wall, staring blankly at his gloved hand while making faint raspberry sounds with his lips.  One cage is open and empty and its rat is nowhere to be seen.


        (puzzled, wondering if he is joking)

     What's the deal, darling?  Tough going with your thesis?

Patton says nothing and gives no sign of recognition, although he does react to her voice, looking frightened and almost ready to start crying like a baby.


  (a look of confused fright crosses her face)

     Are you okay?  (beat)   Pat, what happened?!

She rushes over to him and tries to pull him to his feet but he has clearly forgotten how to stand.  After a few futile tries to get through to him, she realizes that there is something seriously wrong and calls 911, beginning to panic herself at his babbling, blank, vacant responses to everything.

She notices the empty rat cage and the torn glove and the missing rodent, slowly grasping the circumstances but not understanding their full import.

Patton wets his pants as she paces and listens for the ambulance to arrive.

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Avatar of: Corey W

Corey W

Posts: 1

March 3, 2013

Keep on ping-ponging between worlds, Dr. Gambis! Science needs more people like you who can communicate with people from outside its "world."

Avatar of: MonZop


Posts: 9

March 7, 2013

I think there is some confusion between 'science' and 'the scientists'.

The work of Gambis is about the second, which is very important, but does not portray science (i.e. the findings, independent of their finders). Of course, if scientists were just normal people, nobody would want to go to the cinema to see that: movies, and especailly successful movies, are about things extraordinary.

Good work!

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