The chemist examined the role of activated oxygen molecules in biological processes.
Researchers mix cells from human adult gum tissue with tooth-inducing cells from mouse embryos to grow new hybrid teeth complete with roots.
March 12, 2013|
WIKIMEDIA, DOZENISTCells taken from adult human gums can be combined with cells from the molars of fetal mice to form teeth with viable roots, according to research published this week in the Journal of Dental Research. The method remains a long way from clinical use, but the findings represent a step toward the goal of growing bioengineered replacements for lost teeth.
Teeth develop when embryonic epithelial cells in the mouth combine with mesenchymal cells derived from the neural crest. Previous studies have shown that these cells can be combined in the lab to formal normal teeth, but the challenge was to find non-embryonic source of the cells that could be used in the clinic.
To test one such source, a team lead by King’s College London stem cell biologist Paul Sharpe extracted epithelial cells from the gums of adult humans, cultured them in the lab, and mixed them with mesenchymal tooth cells derived from embryonic mice. After a week, the researchers transplanted this mixture into the protective tissue around the kidneys of living mice, where some of the cells developed into hybrid human/mouse teeth containing dentine and enamel, and with growing roots.
The research showed that the epithelial cells from adult human gum tissue responded to tooth-inducing signals from the embryonic mouse tooth mesenchyme, making the gum cells a realistic source for clinical use, said Sharpe in a press release. He added that “the next major challenge is to identify a way to culture adult human mesenchymal cells to be tooth-inducing, as at the moment we can only make embryonic mesenchymal cells do this.”
(Hat tip to BBC News)
March 14, 2013
March 14, 2013
Wow! I woud do anything for a brand new set of teeth. I can't wait till one day they will be offering this in dentistries.
March 15, 2013
omg , your coment is so funny xxif they need a valentear ,,lol, am sure they will let you know,,
March 18, 2013
To sodoff. What's even more funny is you understood his message second I assume you must have had some teeth knocked out. and third look up brain injuries. Amazing.
March 18, 2013
I love that there is still hope for those who have outlasted their second set of teeth!!
The only down side is you develop an overwhelming desire for CHEESE!!
March 21, 2013
Hello , I am amazed and astounded that you have been able to grow a tooth from gum tissue of the patient. My dentist said it would not happen in my life time and that was only 5 years ago. It is at this time that heavy identity took out the wrong tooth during the procedure I was compensated but still dont have a tooth. I am interested in being a test subject. I am a healthy 23 year old who does not smoke at all and drinks moderately. Please email me if this is agreeable at firstname.lastname@example.org
March 24, 2013
This is truely amazing. I used to work in the dental field. It will be almost 10 years now. When i worked in the field change was stagnat. In the 11years I worked in the field there was little change. Nothing of this measure.
P.S. correct spelling... "volunteer" If you are ever unsure google it. Google never disappoints
November 2, 2013
I also would be interested in being a "volunteer". I am 67 years of age, female and in good health except for a little arthritis and bad teeth. So if the reasearch comes to the US, especially Texas, let me know.
P. S. One shouldn't make fun of someone who has less education than them. Some people do not have the opportunities, such as in getting proper dental care. At least this person has read the article and taken the time to respond. Without like willing subjects you wouldn't have some of the medical procedures that are available to you now. Hope all is spelled correctly...did google a couple words :-)
July 23, 2014
Yes, Yes, Please I'd like to Volenteer!!!! use me and don't abuse me but please I want teeth!! :)
Seriously, I'd be a good canditate or I'd mke myself one, what do you need?
November 19, 2014
January 4, 2015
January 24, 2015
Count me in for a volunteer, im here in singapore.
if in case you might need an asian volunteer, im 27 male in good health condition.
i've lost 5 teeth, in wearing denture right now.
Please consider me as your volunteer.
can email me at email@example.com
March 25, 2015
January 12, 2016
Please update me regarding any new technology regarding stem cell or growing another tooth as info becomes available ... I lost a front tooth last month (the cause is not due to gum disease it's ortho & dentistry)... Thank you in advance.
April 9, 2017
I would like to get updates on this researxh. Can anyone give me a url or another way to keep up with this research