GM Rice Could Fight Diarrhea

A genetically modified strain of rice produces an antibody that helps mice fight off rotaviruses.

By | August 13, 2013

WIKIMEDIA, FRITZ GELLER-GRIMMGenetically modified rice could help protect children and the immuno-compromised from diarrheal disease, according to a study published last week (August 8) in The Journal of Clinical Investigation. More than 600,000 children die of rotavirus infections each year, and researchers say the rice could eventually supplement currently available vaccines and other treatments to reduce the rates of rotavirus-related death.

To produce their virus-fighting rice, the researchers inserted genes from llamas in order to get the plants to produce a key section of a rotavirus-targeting antibody, MucoRice-ARP1. This antibody fragment survives digestion, making oral administration possible.

The researchers tested the product in mice, giving them water mixed with rice powder before inoculating the animals with rotavirus. The mice that had received the genetically modified rice water had less diarrhea and a lower viral load than those not given the treatment.

There are already two vaccines available for rotavirus, but they have relatively low efficacy, possibly because they do not work well in immuno-compromised individuals. The researchers suggest that their GM rice could supplement the vaccines, providing protection for the immuno-compromised and infants who are at particularly high risk of diarrheal disease.

But Mathuram Santosham, who studies rotaviruses at Johns Hopkins University, told that “substantially more research is needed to understand the potential impact of this intervention in humans.” She added that, “in the meantime, it is important to remember that we have highly effective tools, which are available now, including rotavirus vaccines, oral rehydration solution, and zinc supplementation.”

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Avatar of: JohnnyBxo


Posts: 3

August 13, 2013

Wouldn't eating this rice after the first time eating it then elicit an immune response because this protein would always be present in the rice and now the individual would have an adaptive response to this protein? Someone help me with the immunity here!

Avatar of: T S Raman

T S Raman

Posts: 51

August 16, 2013

I posted a reply to JohnnyBxo yesterday, but it just did not show up! Nw I am posting it separately.

What the GM rice has is a fragment of the antibody against rotavirus(es), not the antigen of the virus(es). The antibody cannot elicit an immune response against the virus, only the antigen can. 

May I add the following? First, does the antibody fragment survive cooking? I think it is unreasonable to expect humans to eat raw rice. Second, I suggest that scientists should direct their energies towards increasing the efficacy of the vaccines. And third, another plausible approach is to try to produce the human antibody in human cell cutures, for administration to children who have contracted the rotavirus infection. 

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