Recognizing Basic Science Contributions

A “basic bibliography” for new drugs would provide scientists with soft incentives and acknowledge the value of basic biomedical research.

By , , and | January 1, 2014

© SAGE 78/ISTOCKPHOTO.COMBasic biomedical research is key to conquering communicable diseases, which can spread rapidly around the globe, and the noncommunicable conditions behind the premature deaths of an increasing number of people. Many scholars believe that there is a correlation between support for fundamental biomedical research and the improvement of health outcomes, even though knowledge gleaned from basic research usually takes several decades to be applied in the clinic.

Basic research has traditionally been funded in great part by public money. Both small, investigator-initiated studies and large collaborative scientific projects, such as the mapping of the human genome, would have not been possible without public financial support. Unfortunately, however, basic research in the life sciences is usually underfunded.

In the United States, National Institutes of Health funding for all biomedical research has remained relatively stagnant since 2003. And in some countries, basic biomedical research now receives less support than it did just a few years ago.

With limited national budgets, it has become increasingly important to extract maximum transformative value for every biomedical research dollar, and it is necessary to determine how best to incorporate the relative merits of basic biomedical science with its translation to health benefits when devising science policy. Maximizing transformative value will require investing in basic research that is most likely to produce benefits for current and future generations and in scientists who make research of transformative value an overarching goal.

For public health, this goal is achieved if federal funding for basic research is allocated in part by evaluating the future health-benefit potential to society. How to measure the societal impact of research is an emerging topic of discussion in scientific and political communities, and many funding agencies already consider the potential health-benefit significance of a research proposal when assigning funds. However, prediction and measurement of societal impact will likely long remain a difficult task, especially with respect to basic research.

Several types of policies have been proposed to increase the transformative value of basic research. Some aim to foster partnership between academia and industry. One such policy enacted in the U.S. is the Bayh-Dole Act. This legislation provides academic scientists with the possibility of owning their own “inventions.” While some scholars believe this law has not compromised basic biomedical research, many others have criticized it for distracting scientists from very basic studies.

Strong financial incentives, such as those created by Bayh-Dole, will always generate disputes about whether money lures scientists away from important types of basic investigation. For this reason it would be strategic to also design other types of incentives. So-called “soft” incentives, in particular, would create little drive for basic scientists to move to more translational or applied fields, but might be effective in motivating them to do basic research with increased transformative value. Behavioral economists have shown that appealing to intrinsic human motivations can give people a “nudge” (which is the title of a book on the subject by Richard Thaler and Cass Sunstein) toward better choices for themselves and society. In the sciences, such soft incentives could incline some scientists to take their research in a certain direction without imposing any rules or moral obligations, and without decreasing scientific freedom.

An example of a nonfinancial incentive might be a system that formally acknowledges basic scientists when new drugs their research helped to develop are approved. One way to acknowledge this contribution would be to require that a “bibliography of basic papers” accompany each approved drug.

Strong financial incentives will always generate disputes about whether money lures scientists away from important types of basic investigation.

To implement this idea, a peer-review panel would either identify the basic-research papers that were key for the development of the drug, or review a list proposed by the drug-patent owner. Fifty (or more) basic research papers that have been important for development of the applicative work would be selected/approved by the panel and appear in freely accessible databases maintained by the specific agencies. In the U.S., for example, this system could be managed by the Food and Drug Administration; the list of key basic-research papers could be published in the agency’s Orange Book of approved drugs, and perhaps also in the drug’s leaflet. Review-panel members ought to be included as well, to make them both accountable and rewarded. This system should not entail a lot of work for the scientific community; actually, peer-reviewed research papers frequently display many referenced articles, and only a few dozen drugs are approved each year.

For most scientists, we believe this system would instill a small, (partially) subconscious incentive to follow research lines that can more easily lead to future drugs. Such an incentive would work particularly well for drugs that promise to have major impacts in terms of prevention or cure of diseases. This system would sit well with the motivations of scientists, without compromising the basic nature of their research. In fact, this would be a “weak attractor” that would not redirect researcher’s investigations towards less-basic research, but would complement their efforts in unraveling the mysteries of the basic mechanisms of biology. This system would also have the benefit of increasing public awareness of the fundamental role that basic scientists play in drug development, which is often underestimated by both policy makers and the general public.

Andrea Ballabeni is a science policy researcher at the Harvard School of Public Health. Andrea Boggio is an associate professor of legal studies at Bryant University. David Hemenway is a professor of health policy at the Harvard School of Public Health.

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Avatar of: Ken Kaitin

Ken Kaitin

Posts: 1

January 3, 2014

An interesting and thoughtful commentary. I too am concerned that the intense focus in academic research centers (ARCs) on “translational research” or “…science” or “…medicine” is creating a basic research vacuum, which will eventually starve the TR engine itself. This trend originated with Zerhouni’s NIH Roadmap in 2000, and has continued with Collins’s NCATS. As NIH-funded basic research dwindled, ARCs turned to industry as a replacement revenue source. Industry, in the meantime, was suffering from bloated R&D budgets and marginally innovative pipeline candidates, and wanted to tap in to some of the novel research going on in academia. AMCs were more than happy to oblige. The bonus for industry was that companies could reduce their own R&D spend in the process, pleasing investors and shareholders. It was a mutually beneficial, symbiotic relationship. Pfizer's Centers for Therapeutic Innovation are a perfect example of that synergy. The only downside is, Who is going to do the basic research that makes all this translational science possible?

Avatar of: Neurona


Posts: 73

January 27, 2014

Nothing will improve until some survival level of basic research funding can stabilize.  Smart people aren't stupid...  they have choices and they don't choose to gamble their futures.  You can throw all the $ you want at undergraduate research, and even GRADUATE research, but I see it every single day: the cream of that talent pool ultimately rejects research careers for the guaranteed ROI of clinical careers.  

Avatar of: Bob Lowery

Bob Lowery

Posts: 1

January 27, 2014

Recognizing the value of basic research is an important priority, especially in the current environment.  However, it seems that trying to predict which research will be most impactful defeats the purpose to some degree.  Some of the most transformative biological research of the past century was in areas considered to be backwaters at the time; e.g., the work on plasmids that led to recombinant gene technology.  The mistake we make again and again is thinking that we understand biology better than we do. The best approach is to base funding decisions and rewards on the creativity and track record of individual investigators in elucidating how living systems work. Science is fueled by the drive of individuals to explore the unknown.  For some biologists, this has its roots in a desire to cure diseases, and for others it is purely a yearning to decipher nature's mysteries.  The lesson of history is that we should value either motivation equally. 

Avatar of: andrea ballabeni

andrea ballabeni

Posts: 1

Replied to a comment from Bob Lowery made on January 27, 2014

January 29, 2014

Hi Bob

thanks for your comments.

You might also be interested in this research article we have recently published:

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