$1,000 Genome at Last?

Illumina says its newest sequencing system can churn out whole human genomes for $1,000 apiece.

By Tracy Vence | January 15, 2014

WIKIMEDIA, DOE HUMAN GENOME PROJECTIllumina this week claimed to be the first company to achieve the coveted $1,000 genome. While introducing the firm’s new sequencing systems at the annual JP Morgan Healthcare Conference ongoing in San Francisco, CEO Jay Flatley said that, when used at scale, the new HiSeq X Ten system—which comprises 10 integrated sequencers—can process whole human genomes for $1,000 each. Flatley said that the new machine—which is currently limited to human genomes—can partially sequence five genomes per day and complete 16 whole genomes in just three days, MIT Technology Review reported.

The total price tag represents $800 for reagents, $135 for equipment depreciation over four years, and $65 for overhead, such as staff, according to a cost breakdown posted by Mick Waston, head of bioinformatics at Edinburgh Genomics, on his Opiniomics blog.

According to GenomeWeb Daily News, Illumina is only selling the HiSeq X machines in orders of a minimum 10, for a total cost starting at $10 million. The Seoul-based company Macrogen, Australia’s Garvan Institute of Medical Research, and the Broad Institute of MIT and Harvard placed the first three orders for the system.

“Over the next few years, we have an opportunity to learn as much about the genetics of human disease as we have learned in the history of medicine,” the Broad’s Eric Lander said in a statement from the sequencing firm.

Life Technologies, arguably Illumina’s closest competitor in the sequencing market, claimed to have achieved the $1,000 genome with its Ion Torrent technology in 2012. But the machine has not yet made it to market. Life Tech’s Ron Andrews, president of the company’s genetic and medical sciences division, told Bloomberg Businessweek that his firm is still “working on it,” though he added that “there are bigger and more urgent business opportunities than the $1,000 genome.”

But no matter which machines researchers are using to sequence humans genomes, there’s still the question of analysis. “The interpretation (certainly in humans) will need to be done by clinicians, and no, the cost of the clinician is not included in the $1,000,” Watson noted at his blog.

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Avatar of: wctopp


Posts: 110

January 16, 2014

What X coverage is this for $1,000?  Alternatively what's the error rate for $1,000?

Avatar of: tvence


Posts: 1052

Replied to a comment from wctopp made on January 16, 2014

January 16, 2014

Hi wctopp,

Thanks for reading. Illumina claims $1,000 human genome at 30x coverage in its product info sheet, but doesn't mention error rate, which as you note is an important consideration.

Hope this helps!

Tracy Vence

News Editor, The Scientist


Avatar of: AllSeq


Posts: 1

January 16, 2014

This new pricing from Illumina is truly impressive, but not everyone realizes all of the caveats. For example, to achieve the $1000 genome, you’ll need to spend $72M. We’ve walked through all of the details over at the AllSeq blog: http://blog.allseq.com/1000-genome-72m

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