Researchers use DNA origami to generate tiny mechanical devices that deliver a drug that cuts off the blood supply to tumors in mice.
Stress and telomere length in children; osmotic channel protein identified; amoeba nibbles, then kills cells; amphetamine and mental disorder risk; news from AACR
April 11, 2014|
WIKIMEDIA, ASAKO NAKAMURA ET AL.Researchers from Pennsylvania State University have found that a stressful home life is associated with shorter telomeres in a group of nine-year-old boys, and presented evidence to suggest the effects of that stress may be tied to genetic variants. Their work was published in PNAS this week (April 7).
“This study demonstrated this type of differential sensitivity to stress, based on genotype, with telomere shortening early in life,” Elissa Epel from the University of California, San Francisco, who was not involved in the research, told The Scientist by e-mail. “Although the sample is quite small, the data fits theory, and we should pay attention to this alarming story and extend it to other large samples when possible.”
WIKIMEDIA, POLARLYSThe Scripps Research Institute scientists have identified a protein that may be a key piece of volume-regulated anion channels (VRACs), which work to control osmotic pressure and ensure that swelled cells don’t burst. The researchers published their analysis of the protein, which they call SWELL1, in Cell this week (April 10).
While there have been plenty of candidate VRAC proteins over the years, this study is the “first report about one molecule that’s likely forming an ion channel that is mediating this current,” said Jorg Grandl from Duke University in Durham, North Carolina, who was not involved in the work.
KATHERINE RALSTONThe intestinal parasite Entamoeba histolytica destroys host cells first by nibbling them through a process called trogocytosis, investigators from the University of Virginia showed in Nature this week (April 9).
“I have focused my professional career on studying this parasite, and I hadn’t appreciated it [this behavior], nor had anyone else in the field,” study leader William Petri, Jr., told The Scientist.
Liking Amphetamine Linked to Reduced Risk of Mental Disorders
People who report having enjoyed amphetamine are more likely to have gene variants associated with protection against attention deficit-hyperactivity disorder and schizophrenia, a study shows.
Epigenetic Cancer Therapy Clears Phase I
Investigational drug that inhibits proteins involved with epigenetic regulation shows activity against certain blood cancers in an early-stage clinical trial.
Obesity Complicates Colorectal Cancer
Study finds that prediagnosis obesity is predictive of poor prognosis, even among patients who have a molecular marker associated with better disease outcome.
Researchers Regrow Mouse Thymus
A simple genetic formula coaxes a shrunken mouse thymus to regenerate.
Predicting MRSA Toxicity
Comparative genomic study shows that researchers can use genetic signatures to predict the toxicity of methicillin-resistant Staphylococcus aureus isolates.
Lab-Grown Muscle Self-Repairs
Implanted into mice, lab-reared muscle made from stem cells can heal itself after an injury.
Recession Boosts STEM Enrollment
Undergraduate students are more likely to enroll in engineering and biology since the last economic downturn, a survey finds.
As expected, the RIKEN Center for Developmental Biology researcher found guilty of fraud with regard to her stimulus-triggered acquisition of pluripotency (STAP) work said she will appeal her institution’s ruling. During a press conference held in Tokyo this week, Haruko Obokata apologized for problems she has caused for her colleagues in the stem-cell field, ScienceInsider reported, but said that the STAP method is valid. Obokata blamed her own carelessness for the falsification and fabrication charges related to two Nature papers, and told reporters that she had personally created STAP cells more than 200 times.