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In a model of chronic NAD+ depletion that mimics aging, mitochondria are revealed as a rheostat of cellular NAD+ levels.

Scientists identified the mechanism by which a sea cucumber molecule inhibits sulfatase-2, an enzyme that’s often upregulated in cancer.

Microbiomes in older mice pumped out damaging metabolites that drove endothelial cell senescence, offering potential targets for therapeutic intervention.

Distinct microRNA signatures in the saliva of people with endometriosis provide a basis for a non-invasive diagnostic test and shed light on disease biology.

Absence of cysteine in mice coaxed fat-storing cells to burn energy, causing weight loss and offering potential therapeutic targets to improve metabolic health.

A receptor on macrophages dictated their ability to reduce inflammation after liver transplant, offering potential therapeutic targets to avoid complications.

Molecules that build coenzyme Q10, vital for mitochondrial function, healed mice and a patient with an ultra-rare and lethal neurodevelopmental disorder.

As early-onset cancers rise, more people are faced with the question of how their treatment might affect their ability to have children.

Plant biotechnologists are favoring moss factories over other models to produce certain valuable proteins.

Tickling is a strange and intriguing sensation. It’s one that scientists are still working to fully explain.

Collagen IV provides crucial structural support for cells and tissues, but it’s unstable at body temperature. Researchers now identified how it stays together.

After years of debate, scientists provided new evidence for the lifelong birth of human brain cells, which may inform future therapies for neurological diseases.

A specially designed microbe cuts dietary methylmercury levels in pregnant mice, signaling the potential for a new tool for safer seafood consumption.

Proteins involved in neuroinflammation found in the cerebrospinal fluid could help researchers better diagnose and treat chronic fatigue syndrome.

Organizers of Sperm Racing aim to raise awareness for male fertility by timing tiny swimmers in a head-to-head competition.

Cell wall components from Borrelia burgdorferi lingered in the mouse liver for weeks, suggesting new therapeutic avenues for this chronic disease.

By focusing on twins and patients with lupus and Parkinson’s disease, a Mexican consortium is generating critical data to understand health and disease in the country.

Molecular signals after severing an axolotl arm direct the remaining cells how to regrow the limb, offering potential implications for regenerative medicine.

Protecting native maize diversity is one of the key arguments behind Mexico’s constitutional ban on genetically modified corn cultivation.

A deep-learning model trained on human data reveals that promoter mutations may explain a significant portion of unsolved rare diseases.