GM Mosquito Cuts Wild-Type Numbers

Release of a transgenic version of Aedes aegypti, a species that can carry dengue virus, decimated a local population of non-mutated mosquitoes, according to a study.

By Kerry Grens | July 21, 2015

FREESTOCKPHOTOS.BIZ, CDC/PROF FRANK HADLEY COLLINSA genetically modified (GM) mosquito—designed to infiltrate a wild population and produce offspring that die before reproductive age—has devastated local mosquito numbers in a field trial in Brazil. Researchers reported in PLOS Neglected Tropical Diseases this month (July 2) that one year after deployment of the mutant Aedes aegypti, mosquito numbers were reduced 80 percent to 95 percent.

“The fact that the number of Aedes aegypti adults were reduced by 95% in the treatment area confirms that the Oxitec mosquito does what it is supposed to and that is to get rid of mosquitoes,” study coauthor Andrew McKemey, head of field operations at Oxitec, which developed the GM mosquito, said in a press release.

Aedes aegypti can carry pathogens that cause diseases, including dengue and chikungunya. Although McKemey’s study did not determine whether disease burden among humans would drop with the introduction of GM mosquitoes, he said in the statement that “according to published mathematical models reviewed and recommended by the World Health Organization (WHO) working group on dengue, it would . . . reduce the number of biting mosquitoes below the disease transmission threshold.” Durland Fish, an epidemiologist at Yale University, told Popular Science: “Even if it is effective, this technique has shown it can reduce mosquito populations, not disease. It is not one and done.”

The research team released a total of 185,000 mutant male mosquitoes over the course of six weeks by opening the back of a truck as it cruised through the suburban town of Itaberaba, letting the insects fly free. The researchers began by releasing mosquitoes across an 11-hectare area, but the infestation was too great and they cut their target area in half to have a better chance at success.

Oxitec reported an 80 percent drop in mosquito numbers after the release of its Aedes aegypti in Grand Cayman several years ago. Other groups are working on developing mutant Anopheles gambiae, a mosquito that spreads malaria.

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Avatar of: wctopp


Posts: 110

July 21, 2015

They treated about 20 acres, if square it'd be about 1,000 ft square.  That's pretty small, and they specifically were unable to treat more.  They used a space about 30 ft  square to rear the mosquitoes, that's about one unit to rear for every one thousand units treated.  You'd need 30 city blocks to raise the mosquitoes to treat the island of Manhattan.  Prior to use the mosquito populations "were mechanically sorted to remove females" and that doesn't sound highly automated.  By analogy to drug discovery and development this constitutes an active lead compound in laboratory studies and is probably over ten years from any meaningful deployment.  Unfortunately, because it works and I can't see anything that would seriously limit the lifetime of the efficacy (back to the analogy, the equivalent of drug resistance).

Avatar of: swift


Posts: 2

August 5, 2015

This is really interesting stuff. I'd really like to see such studies document the broader effects of wiping out the A. aegypti species on other insects/animals/wildlife, though. These include the species in the direct food chain, and in parallel food chains. It's critical that we check that we're not inadvertently crushing a delicate biological balance in the local ecosystem before such projects are fully deployed.

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