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A human zygote on the first day of development. Both male and female pronuclei and a polar body are clearly visible.

​Scientists Discover a Second Epigenetic DNA Marker

A genetically obese lab mouse.

Targeting a Fat Cell Receptor to Drive Weight Loss

A photo of a female grizzly bear and her cubs.

Bear Necessities: Insights from Grizzly Bears

An image of the tardigrade species Hypsibius exemplaris stained with fluorescent dyes. This tardigrade was stained with LysoTracker Green (cyan), TMRE (magenta), and NucBlue (green). Scale bar: 20μm

Getting Creative with an Extreme Animal Model

Photo of a Russell’s viper against a black background.

How Climate Influences a Deadly Snake’s Venom Chemistry

A transparent, blue 3D model of the human brain glows against a darker blue background. A glowing pink and red tumor sits in the center of the brain, with red tendrils surrounding it and gathering at the base of the brain.

Repurposed Cancer Drug Could Help Treat Brain Tumors

An illustration depicting the fundamental relationship between sound and life. It shows sound waves merging with a DNA helix, over a background of mouse cells.

Sound Waves Can Change Fat Cell Fates

A spiral fossil with a snail-like shell.

Aerobic Bacteria May Predate Earth’s Oxygen Boom

Illustration of a transparent, blue outlined synapse with red neurotransmitters passing between them. More out-of-focus blue neurons are in the background.

ALS Disturbs Sleep Prior to Symptom Onset

A brown-shelled snail with green and white striped eye stalks on the petals of a yellow tiger lily.

How Tiny Organisms Control Minds, Create Zombies, and Shape Ecosystems

Mosquitoes on a red membrane against a white background.

Zika Hacks Host Skin Chemistry to Lure Mosquitoes

Large clumps of bacteria (pink) entrapped by webs of DNA (green) released by neutrophils in human urine.

When a Urinary Tract Infection Strikes, What Protects the Kidneys?

Time-lapsed pictures of a starfish oocyte with light-induced pinching on one end of the cell.

Round Cells Square Up with an Optogenetic Switch

A microscopy image of a retinal organoid graft months after transplantation into the eye of a rat with retinal degeneration. This microscopy image, taken with a Zeiss LSM900 confocal microscope, shows the photoreceptors of the graft organized in rosettes, with their outer segments staining red for rhodopsin and the transplant’s nuclei labeled with a green Ku80 stain. Additionally, DAPI stain (blue) marks both rat and human nuclei.

A Vision of the Future: Restoring Eyesight via Transplantation

A white dire wolf stands in a grassy enclosure in front of a pile of logs.

Dire Wolf De-Extinction Debate Divides Scientists

A human somatosensory pathway recreated in a dish.

Neural Assembloids Recreate a Key Pain-Sensing Circuit in a Dish

A merged brightfield and GFP fluorescence image showing human cells in rats after engraftment

Patching Up Damaged Guts with Healing Cells

Microscopy image of a 120-day old human skin organoid derived from pluripotent stem cells with tentacle-like hair follicles. The green Keratin 5 stain labels the outer layer of the follicles and the epidermis, while the red PMEL stain marks the melanocytes.

Tracking Tissue Development to Inspire Regenerative Therapies

Yellow warning sign "beware of ticks" in the forest.

Developing an Effective Lyme Disease Vaccine

Cross-section of striated skeletal muscle under the microscope

Carving Out a Niche for Muscle Stem Cells with 3D Culture 

Image of a woman in a microbiology lab whose hair is caught on fire from a Bunsen burner.
April 1, 2025, Issue 1

Bunsen Burners and Bad Hair Days

Lab safety rules dictate that one must tie back long hair. Rosemarie Hansen learned the hard way when an open flame turned her locks into a lesson.

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Faster Fluid Measurements for Formulation Development

Meet Honeybun and Breeze Through Viscometry in Formulation Development

Unchained Labs
Conceptual image of biochemical laboratory sample preparation showing glassware and chemical formulas in the foreground and a scientist holding a pipette in the background.

Taking the Guesswork Out of Quality Control Standards

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An illustration of PFAS bubbles in front of a blue sky with clouds.

PFAS: The Forever Chemicals

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Unlocking the Unattainable in Gene Construction

Unlocking the Unattainable in Gene Construction

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