Nailing Down HAR Function

A remaining challenge in the study of human accelerated regions (HARs) is establishing their specific functions during development and other biological processes.

By Katherine S. Pollard | August 1, 2016

Modern stem cell technologies could provide one way to sttudy human accelerated regions (HARs). Using precision gene editors to change the DNA in a chimp cell to match the sequence of a human HAR, for example, researchers can isolate the effects of that HAR. 

© NOVIE STUDIO, 2016, ALL RIGHTS RESERVED

Take skin biopsy from a nonhuman primate.

 

 

 

 

 

 

 

 

© NOVIE STUDIO, 2016, ALL RIGHTS RESERVED

Reprogram skin fibroblasts into brain, heart, or liver cells.

 

 

 

 

 

 

 

 

© NOVIE STUDIO, 2016, ALL RIGHTS RESERVED

Edit the DNA of a specific chimp HAR to match the human sequence.

 

 

 

 

 

 

 

 

© NOVIE STUDIO, 2016, ALL RIGHTS RESERVED

Test the cells for differences in gene expression.

 

 

 

 

 

 

 

 

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