Advantages of Neanderthal DNA in the Human Genome

The retention of ancient hominin DNA in modern human genomes may have helped our ancestors adapt to life in diverse environments. 

By | November 10, 2016

WIKICOMMONS, EINSAMER SCHUTZE The interbreeding of Neanderthals and Denisovans with Homo sapiens resulted in advantageous Neanderthal-inherited alleles in the genomes of a diverse range of modern humans, according to genomicists. The team’s analysis, published today (November 10) in Current Biology, expands the number of loci in the human genome attributed to these ancient hominins. The results suggest that these alleles—mostly within immune and skin pigmentation genes—likely helped modern humans adapt to life outside of Africa.

“The study expands our knowledge of the extent to which Neanderthals and Denisovans contributed functionally relevant genetic variation to modern humans,” Svante Pääbo, an evolutionary geneticist at the Max Planck Institute for Evolutionary Anthropology in Germany, who was not involved in the work, wrote in an email to The Scientist. “It shows that the contribution [of hominin DNA] is substantial and is larger than I assumed when we first discovered that these extinct hominins had mixed with modern human ancestors.”

“The authors’ approach of rebuilding archaic genomes by mining the remnants from modern genomes is unique and brilliant,” wrote Paul Norman, a senior research scientist at Stanford University in California, in an email to The Scientist. “This study adds to the growing body of evidence that modern humans likely survived better in adapting to new environments through breeding with archaic humans.”

As a result of interbreeding between early hominins, the genomes of people from Europe and Asia contain around 2 percent Neanderthal DNA and those of Melanesian decent have an additional 2 percent to 4 percent from Denisovans. Prior work has mapped some of these inherited loci in the human genome, identifying—among other things—immune genes from Neanderthals, which researchers speculate may have provided both Neanderthals and early H. sapiens adaptive advantages against infectious organisms. Another study using medical records showed that the persistence of Neanderthal DNA in individuals’ genomes was linked to certain clinical traits such as depression.

For the present study, Joshua Akey, an evolutionary and computational biologist at the University of Washington, harnessed diverse human genome sequences and new Neanderthal and Denisovan sequences to create a comprehensive picture of adaptive hominin sequences in the human genome. Akey and colleagues used previously constructed genomic maps of around 1 million Neanderthal and Denisovan sequences previously identified in the genomes of modern humans. The researchers then looked for these loci within the genomes of 1,523 individuals of European, South and East Asian, and Melanesian descent. At a 50 percent false-discovery rate, they found 126 genomic loci where ancient hominin DNA appeared to persist at relatively high frequency among these individuals, indicating that the retained locus is likely to confer an evolutionary advantage.

“What’s nice about this paper is that it generates a comprehensive list of potentially adaptive introgressed loci,” said Tony Capra of Vanderbilt University in Nashville, Tennessee, who was not involved in the work.

While individuals of Melanesian ancestry typically retain mostly Denisovan sequences, in the current analysis, the researchers found that 59 percent of the loci in these individuals were Neanderthal in origin.

The 126 loci—including seven previously identified—corresponded to seven genes involved in skin pigmentation and 31 genes that function in immunity. Each locus had a median length of about 81 kilobases. And 80 percent of the loci mapped to regulatory rather than coding regions. “We know that mutations that modulate gene expression are very important for driving divergence between closely related populations and species. But before this study, it was not clear how often introgressed alleles would exert their effects in this way,” Capra told The Scientist.

Analyzing the expression levels of genes associated with the 126 loci, the team found that 13 of the sites varied the expression of 34 genes across different tissue types. One locus resulted in significantly increased expression of a Toll-like receptor (TLR) gene cluster involved in innate immunity in lymphoblast cell lines, and lower expression in primary B cells and fibroblasts. The team tested whether this differential expression was a result of different levels of innate immune system activation. Using whole blood samples from healthy volunteers, they showed that those individuals with Neanderthal-derived TLR alleles could be specifically activated with a TLR4 agonist within immune cells. “We showed that this effect is specific to activated immune cells, which highlights the challenges in interpreting the effect of sequence variation. If you look in the wrong cell type or time point you would never see the effects,” Akey told The Scientist.

“It’s interesting to see that, like alleles that arise by other evolutionary mechanisms, adaptive introgression appears to commonly influence gene expression,” said Capra.

The results provide new clues about one particular route of human evolution. “Instead of waiting for a new beneficial mutation, we can just pick one up by hybridizing with a population that was already adapted to this new environment,” said Akey. “Finding advantageous genes inherited from archaic humans also shows that hybridization was not just some side note to human history, but had important consequences that we can still see in present day individuals.”

Capra agreed. “We are seeing enough of the signature of introgression in human genomes that we really need to integrate it into our models of evolution and selection.”

R.M. Gittelman et al., “Archaic hominin admixture facilitated adaptation to Out-of-Africa environments,” Current Biology, doi:10.1016/j.cub.2016.10.041, 2016.

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Avatar of: marc verhaegen

marc verhaegen

Posts: 17

November 11, 2016

Thanks for this, yes, neandertal genetic admixture may have facilitated our adaptation to different environments, but in a rather specific way. When we biologically compare neandertals & modern humans (Hn & Hs), both subspecies had different but overlapping lifestyles. Hn differed from Hs in having e.g. a very large brain, platycephaly & occipital bunning (long low flat brain-skull), ear exostoses (typical of human divers), a big nose & projecting midface, limited pachyosteosclerosis (heavy but brittle bones), platymeria (dorso-ventrally flattend femora), platypelloidy (strongly flaring ilia,  facilitating femoral abduction), very large lungs etc. Comparative data of other mammals show that most or all these features are typical of littoral and/or wetland species that often dive in shallow waters for sessile foods. IOW, Hn were not the tundra hunters we see in popular descriptions of Hn, but all evidence suggests they collected different sorts of waterside & shallow aquatic foods, e.g. Hn dental plaque has traces of waterlily roots, some Hn tools bear traces of cattails, at the coast Hn collected shellfish & butchered stranded seals & whales (e.g. Gibraltar), they had different species of fish in their diet (e.g. salmon) & butchered carcasses of different waterside herbivores.  Hn fossils & tools are invariably found in river valleys (e.g. oxbow lakes with reeds & beavers) or else at seacoasts: Gibraltar, Italy, Anatolia, Atlantic coasts, Doggerland etc.  All this suggests Hn seasonally followed the river to the sea.  Hs OTOH seems to have been less dependent on the direct nearness of large bodies of water, we lost or reduced the shallow-diving features: Hs has less heavy bones, less large lungs, more basicranial flexion, eyes directed more ventrally rather than rostrally, loss of platycephaly & platymeria, less projecting nostrils etc., but developed narrower bodies (medio-laterally), longer legs, and longer & more caudally directed spinous processes mid-thoracally (stabilising the thoracal spine vertically), which suggest Hs more frequently than Hn waded & walked bipedally.
The different although overlapping lifestyles of Hn & Hs confirm the Coastal Dispersal model of Pleistocene Homo (e.g. Munro 2010): our Pleistocene ancestors did not run over hot open plains as traditionally assumed (this is physiologically impossible e.g. sweat =salt + water is scarce in savannas).  Pleistocene archaic Homo simply followed African & Eurasian coasts & later rivers (some populations even reached islands far overseas: Flores, Sulawesi, Crete, Cyprus etc.) where they collected waterside & shallow aquatic foods, which are so rich in brain-specific nutrients: DHA, iodine, taurine etc.  We have described this more in detail in several publications, e.g. Verhaegen & Munro 2011 "Pachyosteosclerosis suggests archaic Homo frequently collected sessile littoral foods" J.compar.hum.Biol.62:237-247, Verhaegen 2013 "The aquatic ape evolves: common misconceptions and unproven assumptions about the so-called Aquatic Ape Hypothesis" Hum.Evol.28:237-266.

Avatar of: wctopp

wctopp

Posts: 110

November 15, 2016

Neanderthals split off very roughly 500,000 years ago got back in touch/interbred with humans maybe 50,000 years ago.  Assuming a generation is 20 years that's 22,500 generations apart.  I find it inconceivable that neanderthals didn't evolve more than a handful of genes superior to modern humans, yet the claim is that only a couple of percent of our genome is neanderthal.  Convergent evolution?  They evolved their genes just as did we and we wound up functionally little different?  Or perhaps interbreeding was a very rare event after which the hybrid back-crossed to pure human hundreds of times and only the most dramatically beneficial neanderthal genes persevered.  

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