From extending lifespan to bolstering the immune system, the drug’s effects are only just beginning to be understood.
See researchers' recipe for synthetic mesenchymal stem cells, which showed cardiac regenerative potential in mice.
June 1, 2017|
© GEORGE RETSECK. Redrawn from Circ Res, doi:10.1161/CIRCRESAHA.116.310374, 2017, with permission
To create synthetic mesenchymal stem cells (synMSCs), the researchers start with human bone marrow-derived MSCs (1). They combine secretions from these cells with a biodegradable polymer, poly(lactic-co-glycolic acid) or?PLGA, creating microparticles (2). The microparticles are then encased in cell membranes derived from human MSCs (3) to allow the synMSCs to anchor to tissues and gradually release secreted factors, mimicking real MSCs (4).
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