Injecting molecules from a sea slug that received tail shocks into one that didn’t made the recipient animal behave more cautiously.
August 4, 2017
August 4, 2017|
Simmering, low-level inflammation throughout the body is responsible for many disease processes, ranging from osteoarthritis and cardiovascular disease, to digestive disorders and neurodegeneration. The bioactive molecules, known as cannabinoids, found in plants of the Cannabis species, have been shown to possess powerful anti-inflammatory attributes, and research into their mechanisms of action, efficacy, and tolerability are underway. To explore the potential for cannabinoid-based and/or endocannabinoid-targeted therapeutics in the realm of human disease, and particularly diseases with an inflammatory component, The Scientist is bringing together a panel of experts to discuss their research, and to offer insight into the rewards and challenges of studying a biomedical application for a well-known, but controlled, substance. Attendees will have the opportunity to interact with the experts, ask questions, and seek advice on topics related to their research.
Topics to be covered:
Anton Reiner, PhD
Professor, Department of Anatomy and Neurobiology
University of Tennessee Health Science Center
Yannick Marchalant, PhD
Assistant Professor, Departments of Psychology and Neuroscience
Central Michigan University
July 19, 2017
Experimental evidence has clearly shown that certain fucosylated glycans by binding DC-SIGN induce a Th2 anti-inflammatory immunity while inhibiting, but not abrogating the pro-inflammatory Th1/Th17. In fact, a strategy successfully used by certain parasites to prevent the host’s damaging proinflammatory response. I will be quite interested in learning why cannabinoids are superior to the fucosylated glycans? Epidemiological data also shows that proteopathies, like Alzheimer’s disease and autoimmune diseases, caused by inflammatory immune responses, are quite diminished by infection with those parasites. At the risk of being accused of skepticism, I wonder why cannabinoids are now instant celebrities, while fucosylated glycans that have been doing efficiently the same job for millions of years are not. Indeed, in mammals the prevention of fetal rejection and certain cancers’ evasion of immune surveillance are both mediated by fucosylated glycans.
September 25, 2017
The reason is that there has been widespread use of cannibinoids and a resulting body of information about the efficacy and safety (even if not yet sufficiently rigorous) and I am unaware of widespread use of fucosylated glycans and a similar body of information. It is certainly interesting for drug development, but that is a rather different issue.