Researchers did not observe the same link between a bacterium and human colon cancer that prior investigators had reported.
In response to a bacterial infection, an immune signal in mice's guts triggers a molecular cascade that promotes diarrhea, which, researchers demonstrate, is important for ridding them of the bacteria.
June 19, 2017|
Scientists investigating the functional role of diarrhea found that bacterial pathogens stimulate the immune signaling protein IL-22, which increases claudin-2 expression and facilitates the outflow of water and subsequently, diarrhea. According to a news release, this “play[s] a critical role in pathogen clearance in the early stages of infection.”
See P.-Y. Tsai et al., “IL-22 upregulates epithelial claudin-2 to drive diarrhea and enteric pathogen clearance,” Cell Host & Microbe, doi:10.1016/j.chom.2017.05.