Image of the Day: Un-break My Heart

A failing heart is easily distinguished from a healthy one by numerous tell-tale signs, including its slender, stretched-out walls, increased size, and pooled blood clots.

By | August 8, 2017

Healthy (left) and failing (right) mouse hearts. A blood clot noticeably pools in the top right chamber of the failing heart.GRUETER LABORATORY, UNIVERSITY OF IOWA HEALTH CARE Researchers recently unearthed gene expression patterns in heart tissues from a mouse model of heart failure that were noticeable before the mice’s hearts began to show symptoms. These patterns mimicked those observed in diseased human heart cells.

“In terms of disease progression, heart failure is the end stage,” says senior author Chad Grueterin a news release. “Our study suggests that the transition, or ‘switch,’ from a stressed, enlarged heart to a failing heart is key. Looking ahead, hopefully we’ll be able to test whether a drug can block that switch from occurring.”

See D.D. Hall et al., “Ectopic expression of Cdk8 induces eccentric hypertrophy and heart failure,” JCI Insight2:e92476, 2017.

Add a Comment

Avatar of: You

You

Processing...
Processing...

Sign In with your LabX Media Group Passport to leave a comment

Not a member? Register Now!

LabX Media Group Passport Logo

Popular Now

  1. Thousands of Mutations Accumulate in the Human Brain Over a Lifetime
  2. Two Dozen House Republicans Do an About-Face on Tuition Tax
  3. Can Young Stem Cells Make Older People Stronger?
  4. Putative Gay Genes Identified, Questioned
    The Nutshell Putative Gay Genes Identified, Questioned

    A genomic interrogation of homosexuality turns up speculative links between genetic elements and sexual orientation, but researchers say the study is too small to be significant. 

FreeShip