In Drosophila, the tissue is more permeable to drugs at night, offering a possible explanation for why some medicines work better at certain times of day.
The protein encoded by the gene that causes Fragile X in humans partners with another protein, dNab2, to alter gene expression in fruit fly neurons.
August 10, 2017|
KEN MOBERG Scientists demonstrate that the protein FMRP, encoded by the disease-initiating gene in Fragile X syndrome, doesn’t work alone to alter gene expression in fruit fly neurons. Instead, it partners with the RNA-binding protein dNab2.
See R.S. Bienkowski et al., “The conserved, disease-associated RNA binding protein dnab2 interacts with the fragile x protein ortholog in drosophila neurons,” Cell Reports, 20:1327-84, 2017.