Growth-Promoting Protein Linked to REM Sleep in Rats

Brain-derived neurotrophic factor affects onset and duration of REM in the animals, but not other phases of sleep.

By | November 12, 2017

FLICKR; TOMI TAPIO KBrain-derived neurotrophic factor (BDNF), a protein linked in previous research to long-term memory and to multiple brain-related diseases in humans, helps rats regulate when and for how long they slip into rapid eye-movement (REM) sleep, a new study finds. The work, by Jennifer Garner, Subimal Datta, and colleagues at the University of Tennessee, appears in a poster presented at the annual Society for Neuroscience meeting this weekend.

The researchers genetically altered rats to produce 50 percent of the normal amount of BDNF, and using electrodes implanted in the animals’ brains, compared their sleep patterns to that of normal rats used as controls. They found that the rats with lower levels of BDNF had fewer and shorter bouts of REM sleep than the normal rats, Garner said at a poster presentation on November 11.

Next, the team deprived all of the rats of just REM sleep for three hours, by monitoring their brain waves and using a device to lift a rat’s head when they saw it going into REM sleep. Garner and colleagues had expected that after the three-hour period ended and the rats were allowed to sleep normally, they would go quickly into REM sleep and spend more time in REM than usual to compensate for the deprivation, and that’s exactly what happened in the normal rats. But the genetically altered animals continued to take longer to slip into REM sleep, and stayed in that state for relatively short periods of time.

The study shows that BDNF plays a role in regulating REM sleep, Garner says—a finding that meshes with earlier research. The protein’s levels have previously been shown to increase following exercise in rats and humans, for example, and exercise, in turn, has been linked to better sleep. Conversely, low levels of BDNF have been linked to depression, which is often associated with sleep disruptions.

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