The chemist examined the role of activated oxygen molecules in biological processes.
A heat map of gene expression provides insights on the genes that help C. elegans survive severe caloric restriction.
November 14, 2017|
JONATHAN HIBSHMAN & RYAN BAUGH / DUKE UNIVERSITY The nematode worm Caenorhabditis elegans is a popular model to study the physiological reponses that allow animals to cope with starvation. When population densities are high and food is limited, C. elegans will form specialized larval forms—so-called “dauer” larvae—that can survive for months in nutrient-poor conditions, or enter a state of developmental arrest until they feed. To explore the genetics involved in this survival adaptation, scientists took a close look at one gene, known as tps-1, that is involved in synthesizing trehalose, a sugar that helps protect the worms from desiccation and other types of stress. They found that tps-1 expression and trehalose synthesis increases during starvation periods, demonstrating its role as a stress protectant.
See J.D. Hibshman et al., “daf-16/FoxO promotes gluceogenesis and trehalose synthesis during starvation to support survival,” eLife, doi:10.7554/eLife.30057, 2017.