Image of the Day: Actin Burst

Researchers are looking at actin polymerization and calcium uptake in human cells to study mitochondrial division.

By The Scientist Staff | December 6, 2017

A human osteosarcoma cell labeled for actin filaments (green) and mitochondrial calcium (red) whilst treated with ionomycinRAJARSHI CHAKRABARTI, GEISEL SCHOOL OF MEDICINE AT DARTMOUTH Actin polymerization and calcium signaling play an important role in division of mitochondria. To study this process in depth, researchers treated human osteosarcoma cells with a specific compound—ionomycin—to raise the calcium levels within them. This caused a rapid polymerization of actin filaments, quickly followed by an increase in mitochondrial calcium.

R. Chakrabarti et al., “INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division,” J Cell Biol, doi:10.1083/jcb.201709111, 2017.

Add a Comment

Avatar of: You



Sign In with your LabX Media Group Passport to leave a comment

Not a member? Register Now!

LabX Media Group Passport Logo

Popular Now

  1. Two University of Rochester Professors Resign in Protest
  2. Dartmouth Professor Investigated for Sexual Misconduct Retires
  3. Theranos Leaders Indicted For Fraud
    The Nutshell Theranos Leaders Indicted For Fraud

    Federal prosecutors filed criminal charges that allege the company’s promise to revolutionize blood testing swindled investors out of hundreds of millions of dollars and put patients in danger.

  4. Koko the Signing Gorilla Dies at 46