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A photo of a female grizzly bear and her cubs.

Bear Necessities: Insights from Grizzly Bears

An image of the tardigrade species Hypsibius exemplaris stained with fluorescent dyes. This tardigrade was stained with LysoTracker Green (cyan), TMRE (magenta), and NucBlue (green). Scale bar: 20μm

Getting Creative with an Extreme Animal Model

A spiral fossil with a snail-like shell.

Aerobic Bacteria May Predate Earth’s Oxygen Boom

Illustration of a transparent, blue outlined synapse with red neurotransmitters passing between them. More out-of-focus blue neurons are in the background.

ALS Disturbs Sleep Prior to Symptom Onset

A brown-shelled snail with green and white striped eye stalks on the petals of a yellow tiger lily.

How Tiny Organisms Control Minds, Create Zombies, and Shape Ecosystems

Mosquitoes on a red membrane against a white background.

Zika Hacks Host Skin Chemistry to Lure Mosquitoes

Large clumps of bacteria (pink) entrapped by webs of DNA (green) released by neutrophils in human urine.

When a Urinary Tract Infection Strikes, What Protects the Kidneys?

Time-lapsed pictures of a starfish oocyte with light-induced pinching on one end of the cell.

Round Cells Square Up with an Optogenetic Switch

A microscopy image of a retinal organoid graft months after transplantation into the eye of a rat with retinal degeneration. This microscopy image, taken with a Zeiss LSM900 confocal microscope, shows the photoreceptors of the graft organized in rosettes, with their outer segments staining red for rhodopsin and the transplant’s nuclei labeled with a green Ku80 stain. Additionally, DAPI stain (blue) marks both rat and human nuclei.

A Vision of the Future: Restoring Eyesight via Transplantation

A white dire wolf stands in a grassy enclosure in front of a pile of logs.

Dire Wolf De-Extinction Debate Divides Scientists

A human somatosensory pathway recreated in a dish.

Neural Assembloids Recreate a Key Pain-Sensing Circuit in a Dish

A merged brightfield and GFP fluorescence image showing human cells in rats after engraftment

Patching Up Damaged Guts with Healing Cells

Microscopy image of a 120-day old human skin organoid derived from pluripotent stem cells with tentacle-like hair follicles. The green Keratin 5 stain labels the outer layer of the follicles and the epidermis, while the red PMEL stain marks the melanocytes.

Tracking Tissue Development to Inspire Regenerative Therapies

Yellow warning sign "beware of ticks" in the forest.

Developing an Effective Lyme Disease Vaccine

Cross-section of striated skeletal muscle under the microscope

Carving Out a Niche for Muscle Stem Cells with 3D Culture 

Illustration showing the synapses from two neurons connecting.

To Fuel Their Growth, Cancer Cells Hijack Neurons

A hand holding multiple injection pens.

Scientists Who Pioneered GLP-1 Drugs Bag Breakthrough Prize

Image of two nerve fibers next to each other. The one on the left has its myelin sheath intact, while the other has damaged myelin sheaths.

2025 Breakthrough Prize Recognizes Trailblazers in Multiple Sclerosis Research

Hands wearing blue gloves use scissors and forceps to cut DNA.

David Liu Wins 2025 Breakthrough Prize for Base Editing and Prime Editing

An illustration showing diverse protein domains, represented as squiggly gray structures, on a black background.

Unstable Protein Variants Linked to Many Human Diseases

Image of a woman in a microbiology lab whose hair is caught on fire from a Bunsen burner.
April 1, 2025, Issue 1

Bunsen Burners and Bad Hair Days

Lab safety rules dictate that one must tie back long hair. Rosemarie Hansen learned the hard way when an open flame turned her locks into a lesson.

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Conceptual image of biochemical laboratory sample preparation showing glassware and chemical formulas in the foreground and a scientist holding a pipette in the background.

Taking the Guesswork Out of Quality Control Standards

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An illustration of PFAS bubbles in front of a blue sky with clouds.

PFAS: The Forever Chemicals

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Unlocking the Unattainable in Gene Construction

Unlocking the Unattainable in Gene Construction

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Concept illustration of acoustic waves and ripples.

Comparing Analytical Solutions for High-Throughput Drug Discovery

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