Infographic: A Prion Assay

An approach called yeast transcriptional reporting of aggregating proteins allows for high-throughput analysis and doesn’t destroy cells.

By Ruth Williams | February 1, 2018

© GEORGE RETSECKTo detect clumping of a protein of interest, express it together with a synthetic transcriptional activator domain (grey). If the protein remains soluble, the reporter gene (green), which is under the control of a synthetic promoter that corresponds to the activator, will be expressed. If the proteins clump together, it will not.

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