From extending lifespan to bolstering the immune system, the drug’s effects are only just beginning to be understood.
At Hampshire College, students and faculty use the amoeba Physarum polycephalum—both a “visiting scholar” and a model organism—to examine human societal and political quandaries.
March 2, 2018|
RAINA MENDELSince the spring of 2017, Hampshire College has had an unusual visiting scholar: the acellular slime mold Physarum polycephalum. This idea came from conceptual artist and experimental philosopher Jonathon Keats, who invited the slime molds to model various scenarios of human societal problems, and potentially offer solutions.
“Because slime molds are totally other, it means that they can potentially serve as outsiders, where they don’t have any inherent human biases, and we can all come around to observing their behavior to pay heed to their advice,” Keats says.
Over the last year, with help from Keats, biology professor Megan Dobro, and Hampshire College Art Gallery director Amy Halliday, Hampshire undergraduates have used P. polycephalum to examine human quandaries, from border policy to drug addiction, in a project known as the Plasmodium Consortium. The results of their experiments are the subject of a symposium today (March 2) at Hampshire.
P. polycephalum spends most of jts life cycle as a giant, motile cell, known as a super-organism, that contains many genetically distinct nuclei yet acts as a unit, exhibiting cooperative behavior to optimize conditions for the whole. In addition to its collaborative tendencies, the slime mold is known for its engineering ability; when placed on a map of the U.S. with food sources at major cities, P. polycephalum branches out in a pattern like that of the US highway system.
Humans don’t need slime molds to design highways, Keats recalls thinking, but could they help us with other problems?
Human society is also like a super-organism, he says, in that individuals’ decisions affect the whole, but we’re not so good at cooperating. “We can . . . look to the slime mold as a way of being able to see how we might behave for our collective good,” Keats says. “Maybe if we were to enlist slime molds to solve problems that are more vexing for society [than civil engineering] . . . they might be able to come up with insights that would be beneficial to us.” Toward this end, the students used the slime molds to examine border policy, addiction, materialism, food deserts, and public transportation.
For instance, the addiction experiment examined, by analogy, whether gateway drugs, such as marijuana, lead to further drug use. For P. polycephalum, valerian root is addictive and harmful—equivalent, the researchers posit, to hard drugs. “If you place the slime mold on a Petri dish where it has access to valerian root and access to food, it will choose the valerian root, and it will be to its detriment; it will often die as a result of that poor decision,” Keats says. The situation is a binary choice: hard drugs or no drugs.
RAINA MENDELSo the researchers asked: Given access to a gradient of valerian root across a Petri dish, where do slime molds situate themselves? The researchers think of the gradient as a drug spectrum: the center, where valerian is most concentrated, represents hard drugs; the middle of the Petri dish are the “gateway drugs” of moderate valerian concentrations; and no drugs are present at the rim of the dish. The investigators found that slime molds that started near the pure valerian root migrated outward along the gradient toward areas with lower concentrations of valerian, whereas those placed near the rim migrated less toward the center.
The “gateway drugs” of moderate valerian abundance appeared to pull the slime molds away from the pure valerian root to a greater extent than it pulled sober slime molds toward it. To Keats, these asymmetrical migrations suggest that gateway drugs do not lead to further drug use but, rather, serve as less-harmful alternatives to hard drugs.
In his role as consortium secretary, Keats has briefed officials at the United Nations, the Department of Homeland Security, and other relevant political bodies on the experimental results and what he views as their policy implications. For example, in a letter to Attorney General Jeff Sessions, Keats writes: “Preliminary results from the plasmodial research group suggest that cannabis and its chemical derivatives should be legalized by the United States government.” The Department of Justice has not yet responded.