The Challenges of Precision
Researchers face roadblocks to treating an individual patient’s cancer as a unique disease.
Control ALT, Delete Cancer
Treating cancer by shutting down the alternative lengthening of telomeres (ALT) pathway
Bursting Cancer’s Bubble
Scientists make oxygen-filled microbubbles designed to increase tumor sensitivity to radiation.
Toggling Between Life and Death
In estrogen receptor–positive breast cancer, the transcription factor IRF1 tips the balance between cellular suicide and survival through autophagy.
Activating signaling pathways, rather than individual genes, reveals roles for both growth and dedifferentiation in establishing resistance to cancer treatments.
Gut bacteria control tumor growth via the mammalian immune system.
Charles Sawyers, who began his research career just as the genetic details of human oncogenes were emerging, codeveloped Gleevec, the quintessential targeted cancer therapy.