Cancer's Grip

Volume 30 Issue 4 | April 2016

Featured Articles

image: A Different Way of Doing Things

A Different Way of Doing Things

By Kivanç Birsoy and David M. Sabatini | April 1, 2016

Cancer cells exhibit altered metabolic processes that may serve as promising targets for new therapies.

image: Microbes Meet Cancer

Microbes Meet Cancer

By Kate Yandell | April 1, 2016

Understanding cancer’s relationship with the human microbiome could transform immune-modulating therapies.

image: The Forces of Cancer

The Forces of Cancer

By Lance L. Munn and Rakesh K. Jain | April 1, 2016

A tumor’s physical environment fuels its growth and causes treatment resistance.




Meet some of the people featured in the April 2016 issue of The Scientist.


Shooting for the Moon

Defeating cancer is many times more difficult than planting a flag on our lunar satellite.

Speaking of Science

Speaking of Science

April 2016's selection of notable quotes


A Tree Takes Root

Four apparently unrelated individuals share a common ancestor from whom they inherited a rare mutation that predisposed them to the cancer they share.

Putting the Pee in Pluripotency

One man’s waste is another man’s treasure trove of stem cells.

The Two Faces of Fish Oil

The discovery of a tumor-protecting role for a fatty acid found in fish oil has sparked debate about the product’s safety.

Cancer Be Damned

Teenager Lauren Bendesky turned her cancer diagnosis on its head, using herself as a research subject to test potential therapies.

Critic at Large

Pet Scans

Studying tumor development and treatment in dogs and cats, in parallel with research on rodents and humans, could improve the successful translation of new cancer drugs.

Online First

Two-Way Traffic

In mice, malignant cells genetically modified to express an anticancer cytokine home in on tumors and reduce their growth.

Modus Operandi

Tumor-Shrinking Triple-Helices

A braided structure and some adhesive hydrogel make therapeutic microRNAs both stable and sticky.

The Literature

Cancer's Vanguard

Exosomes are emerging as key players in metastasis.

Tumor Traps

After surgery to remove a tumor, neutrophils recruited to the site spit out sticky webs of DNA that aid cancer recurrence.

Cancerous Conduits

Metastatic cancer cells use nanotubes to manipulate blood vessels.


Guts and Glory

An open mind and collaborative spirit have taken Hans Clevers on a journey from medicine to developmental biology, gastroenterology, cancer, and stem cells.

Scientist to Watch

Pradeep Chaluvally-Raghavan: Curious about Cancer

Instructor, Department of Systems Biology, University of Texas MD Anderson Cancer Center. Age: 38

Lab Tools

Pulling It All Together

Systems-biology approaches offer new strategies for finding hard-to-identify drug targets for cancer.

Written in Blood

A tour of evolving strategies for identifying circulating disease biomarkers

Bio Business

Banking on Blood Tests

How close are liquid biopsies to replacing current diagnostics?

Reading Frames

Parallel Plagues

Like cancer, ecological scourges result from the breakdown of regulatory processes, and may be treated with similar logic.

Capsule Reviews

Capsule Reviews

Lab Girl, The Most Perfect Thing, Half-Earth, and Cosmosapiens


Fighting Cancer with Infection, 1891

Now hailed as the father of immunotherapy, William Coley pioneered extraordinary methods to treat cancer.

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