The Transgender Brain

Volume 32 Issue 3 | March 2018

Cover Story

Research into the biological basis of gender identity is in its infancy, but clues are beginning to emerge.

Featured Articles

image: Eat Yourself to Live: Autophagy’s Role in Health and Disease

Eat Yourself to Live: Autophagy’s Role in Health and Disease

By Vikramjit Lahiri and Daniel J. Klionsky | March 1, 2018

New details of the molecular process by which our cells consume themselves point to therapeutic potential.

image: Paleoproteomics Opens a Window into the Past

Paleoproteomics Opens a Window into the Past

By Catherine Offord | March 1, 2018

Researchers are looking to proteins to explore the biology of ancient organisms, from medieval humans all the way back to dinosaurs.




Meet some of the people featured in the March 2018 issue of The Scientist.


The Skin We’re In

How can science inform the debate on gender?

Speaking of Science

Ten-Minute Sabbatical

Take a break from the bench to puzzle and peruse.


Study Finds Epigenetic Differences Between Hatchery-Raised and Wild-Born Salmon

The variation may help explain why stocked salmon don’t fare as well in the ocean.

UK Judges Receive Primers on Forensic Science

Scientists in the U.K., in collaboration with members of the judiciary, have launched the first in a series of explanatory documents designed to help integrate science into the courtroom.

Could Rapamycin Help Humans Live Longer?

From extending lifespan to bolstering the immune system, the drug’s effects are only just beginning to be understood.


Stressed Rodents Make Different Choices

Chronic stress tweaks a circuit in the brain that influences how lab rodents make tough decisions. 

Modus Operandi

Here Comes Single-Cell Optogenetics

A new protein may allow researchers to home in on individual neurons, determining their activity minute by minute.

The Literature

Bacterial Cell Envelope Size is Key to Membrane Stress Response

Transmission of stress signals in E. coli is dependent on the distance between its inner and outer membranes.

Circulating Mitochondrial DNA Alerts Immune System to Danger

In response to short DNA fragments, lymphocytes release mitochondrial DNA that helps trigger an immune response.

A Systematic Approach to Finding Unannotated Proteins

A study suggests that there is more to the eukaryotic genome than was previously suspected.


Parasitologist, Reprogrammed: A Profile of David Roos

After discovering a novel organelle found in protozoan parasites, the University of Pennsylvania’s Roos created a widely used eukaryotic pathogen database.

Scientist to Watch

Jermaine Jones Seeks to Untangle the Genetics Behind Substance Abuse

Studying pharmacogenetics in lab rodents prepared the Columbia University professor to investigate the biological underpinnings of substance use disorders in humans.

Lab Tools

New Methods to Detect CRISPR Off-Target Mutations

Researchers have developed a variety of techniques to detect when CRISPR misses the mark.


How to Successfully Collaborate with Industry

In efforts to translate basic-science results into pharmaceuticals and other technologies, success cannot be taken for granted.

Reading Frames

The Forgotten History of World War I–Era Female Scientists

As millions of men headed off to fight in the Great War, women researchers stayed behind to further science. Their struggle for equality rages on today.


The Child Hatchery, 1896

The incubator exhibitions of the late 19th and early 20th centuries publicized the care of premature babies.

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