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Middle aged woman sitting on a sofa, holding her knee in pain.
Bone-Building Hormone Identified in Lactating Mice 
Claudia Lopez-Lloreda, PhD | Dec 3, 2024 | 4 min read
A brain-derived hormone that improves bone health could guide new treatments for age-related bone conditions. 
Three-dimensional rendering of violet-colored astrocytes touching a red blood vessel.
Modeling the Blood-Brain Barrier in a Dish
Sneha Khedkar | Dec 3, 2024 | 4 min read
Human brain and blood vessel organoids merged to form blood-brain barrier assembloids could provide clues into neurological diseases.
Discover How Single-Cell Sequencing Can Clarify Tumor Complexity
Molecular-Level Dissection of the Tumor Microenvironment 
10x Genomics | Dec 2, 2024 | 1 min read
An immuno-oncology targeting panel accurately characterized tumor-resident immune cells and located pathologically and clinically relevant tumor microenvironment features. 
Image of concentric circles cut into a grass lawn.
Bacteria’s Stress Strategy: Slow Down to Avoid the Crowd
Laura Tran, PhD | Dec 2, 2024 | 4 min read
Computer simulations highlight how bacteria slow their growth to avoid overcrowding, a behavior that may inform pathogen control. 
A woman in a blue and white striped shirt crosses her fingers behind her back.
How Does the Placebo Effect Work?
Hannah Thomasy, PhD | Dec 2, 2024 | 2 min read
Placebo analgesia might be all in the head, but that doesn’t mean it’s not real.
Image of an axon, with a callout box highlighting a portion of the cell membrane. It depicts three different electrodes and ion channels along the membrane.
What’s the Difference Between a Voltage Clamp and a Current Clamp?
Laura Tran, PhD | Dec 2, 2024 | 2 min read
Depending on the “clamped” parameter, patch clamp configurations probe different aspects of a cell's electrical activity.
A photo of a 96-well microplate showcasing serial dilutions of purple dye solution.
Achieving Consistency in Serial Dilutions
The Scientist Staff | Dec 2, 2024 | 2 min read
Researchers ensure the success of their serial dilution-based assays by using optimized protocols and advanced liquid handling tools.
A panel of six screenshots from the computer animated game Microscopya, developed by Beata Science Art.
Playing Games to Learn Cell Biology
Shelby Bradford, PhD | Dec 2, 2024 | 2 min read
Video games get microscopic in an educational science outreach project.
Immunofluorescence image of a cross-section of a term placenta showing STB and CTB labeled pink and surrounding nuclei and nuclear speckles labeled blue and green, respectively. 
A Tissue-Sized Cell with Billions of Nuclei 
Danielle Gerhard, PhD | Dec 2, 2024 | 2 min read
Single-nucleus RNA sequencing revealed specialized regions within the placenta's multinucleated cell.
A young child holding her bruised knee.
A Beneficial Bacterium Helps Wounds Heal
Sneha Khedkar | Dec 2, 2024 | 5 min read
A bacterium found in the wound microbiome can accelerate healing, highlighting the potential for microbiota-based wound therapies.
A 3D rendered model of a glutamic acid molecule with other organic molecules floating around it.
Protein Makeover with Custom Amino Acids
Laura Tran, PhD | Dec 2, 2024 | 2 min read
With a plug-and-play strategy, researchers engineer proteins with new functions.
<em>The Scientist</em> December crossword puzzle
Science Crossword Puzzle
Stella Zawistowski | Dec 2, 2024 | 1 min read
Put on your thinking cap, and take on this fun challenge.
A bowl filled with various nuts, beans, seeds, avocado, oats, cheeses, and meat, is arranged by color to form a yin-yang symbol. The background is filled with cartoon images of cells.
A Keto Diet Could Enhance Cancer Drug Effectiveness
Paige Nicklas | Nov 29, 2024 | 4 min read
In mice, a ketogenic diet remodeled the translatome of pancreatic cancer cells, rendering them vulnerable to targeted therapy.
An illustration showing a DNA strand and a cancer cell.&nbsp;
How Some Cancer Cells Survive Chemotherapy
Sahana Sitaraman, PhD | Nov 26, 2024 | 4 min read
Chemotherapy drugs can kill cancer cells by halting DNA replication, but a glucose-depleted environment can help cancer cells overcome this effect and resist death. 
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