D.D. Ho, A.U. Neumann, A.S. Perelson, W. Chen, J.M. Leonard, M. Markowitz, "Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection," Nature, 373:123-6, 1995. (Cited in nearly 100 publications through November 1995)
Comments by Martin Markowitz, Aaron Diamond AIDS Research Center, New York
According to Martin Markowitz, a staff investigator at the Aaron Diamond AIDS Research Center of the New York University School of Medicine, the main significance of this paper is that "it establishes high levels of viral production as the engine that drives the disease in HIV-1 pathogenesis."
High levels of virus had always been correlated with the end stages of HIV infection, characterized by the depletion of helper T cells -- also called CD4 lymphocytes -- and the progression of the disease. But, Markowitz notes, until now, the research community had little insight into the rates of viral and T- cell turnover in...
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