D. Scheuner, C. Eckman, M. Jensen, X. Song, M. Citron, N. Suzuki, T.D. Bird, J. Hardy, M. Hutton, W. Kukull, E. Larson, E. Levy-Lahad, M. Viitanen, E. Peskind, P. Poorkaj, G. Schellenberg, R. Tanzi, W. Wasco, L. Lannfelt, D. Selkoe, S. Younkin, "Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease," Nature Medicine, 2:864-70, 1996. (Cited in more than 270 papers since publication)

Comments by Steven G. Younkin, director of research and professor of pharmacology at the Mayo Clinic in Jacksonville, Fla.

Amyloidß plaques have been showing up in lots of places. They appear to play a major role in Creutzfeld-Jacob's disease--the human analogue of the neurodegenerative mad cow disease--and they've been linked to Alzheimer's disease (AD). (See story, opposite page.)

Steven G. Younkin
In AD,...

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