Johanna Pruller, PhD

Johanna Pruller is a research associate at King’s College London where she previously obtained a PhD in molecular medicine and focused on the development of a gene therapy for alveolar rhabdomyosarcoma. She has since then studied cancer heterogeneity and its consequence on why therapies fail and how tumor cells acquire resistance mechanisms.

Articles by Johanna Pruller, PhD

3D structural model of a Cas protein and sgRNA targeting and unwinding DNA for gene editing.

CRISPR Gene Editing: Cas9 and Beyond

Johanna Pruller, PhD and Deanna MacNeil, PhD | Nov 29, 2023 | 7 min read

Researchers create and improve CRISPR-Cas mediated gene editing technologies based on prokaryotic CRISPR systems and eukaryotic DNA repair mechanisms.

Abstract rendering of a tumor and its microenvironment in purple

The Basics of the Tumor Microenvironment

Johanna Pruller, PhD | Jun 15, 2023 | 4 min read

Learn about the tumor microenvironment (TME), a key influencer of cancer growth, spread, and treatment success.